ReviewAnnual review of biomedical engineering2012
Nonlinear dynamics in cardiology.
Review in Annual review of biomedical engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Intracellular ion accumulation in the genesis of complex action potential dynamics under cardiac diseases.Physical review. E · 2024Article
- Long-term changes in heart rate and electrical remodeling contribute to alternans formation in heart failure: a patient-specific in silico study.American journal of physiology. Heart and circulatory physiology · 2023Article
- Circadian Rhythms of Early Afterdepolarizations and Ventricular Arrhythmias in a Cardiomyocyte Model.Biophysical journal · 2021Article
- Advances in Cardiac Pacing: Arrhythmia Prediction, Prevention and Control Strategies.Frontiers in physiology · 2021Review
- Detection of Drug-Induced Torsades de Pointes Arrhythmia Mechanisms Using hiPSC-CM Syncytial Monolayers in a High-Throughput Screening Voltage Sensitive Dye Assay.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Sensitivity and Uncertainty Analysis of Two Human Atrial Cardiac Cell Models Using Gaussian Process Emulators.Frontiers in physiology · 2020Article
- Large-scale Interactive Numerical Experiments of Chaos, Solitons and Fractals in Real Time via GPU in a Web Browser.Chaos, solitons, and fractals · 2019Article
- Heart rate variability based machine learning models for risk prediction of suspected sepsis patients in the emergency department.Medicine · 2019Observational
- Serial Heart Rate Variability Measures for Risk Prediction of Septic Patients in the Emergency Department.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2019Article
- Article
- Control of voltage-driven instabilities in cardiac myocytes with memory.Chaos (Woodbury, N.Y.) · 2018Article
- The CaeLife · 2018Article
- A novel heart rate variability based risk prediction model for septic patients presenting to the emergency department.Medicine · 2018Observational
- Memory-induced nonlinear dynamics of excitation in cardiac diseases.Physical review. E · 2018Article
- A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research.Frontiers in physiology · 2018Review
- Patient-Specific Identification of Atrial Flutter Vulnerability-A Computational Approach to Reveal Latent Reentry Pathways.Frontiers in physiology · 2018Article
- Period doubling cascades of limit cycles in cardiac action potential models as precursors to chaotic early Afterdepolarizations.BMC systems biology · 2017Article
- Memory-Induced Chaos in Cardiac Excitation.Physical review letters · 2017Article
- Stochastic initiation and termination of calcium-mediated triggered activity in cardiac myocytes.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A unified theory of calcium alternans in ventricular myocytes.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The dynamics of many cardiac arrhythmias, as well as the nature of transitions between different heart rhythms, have long been considered evidence of nonlinear phenomena playing a direct role in cardiac arrhythmogenesis. In most types of cardiac disease, the pathology develops slowly and gradually, often over many years. In contrast, arrhythmias often occur suddenly. In nonlinear systems, sudden changes in qualitative dynamics can, counterintuitively, result from a gradual change in a system parameter-this is known as a bifurcation. Here, we review how nonlinearities in cardiac electrophysiology influence normal and abnormal rhythms and how bifurcations change the dynamics. In particular, we focus on the many recent developments in computational modeling at the cellular level that are focused on intracellular calcium dynamics. We discuss two areas where recent experimental and modeling work has suggested the importance of nonlinearities in calcium dynamics: repolarization alternans and pacemaker cell automaticity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.