ArticleImmunity & ageing : I & A2012
Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity.
Article in Immunity & ageing : I & A, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Modulation of miR-146b Expression during Aging and the Impact of Physical Activity on Its Expression and Chondrogenic Progenitors.International journal of molecular sciences · 2023Article
- Longevity, Centenarians and Modified Cellular Proteodynamics.International journal of molecular sciences · 2023Review
- Epigenetic regulation of aging: implications for interventions of aging and diseases.Signal transduction and targeted therapy · 2022Review
- AD-associated CSF biomolecular changes are attenuated in KL-VS heterozygotes.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Omics in a Digital World: The Role of Bioinformatics in Providing New Insights Into Human Aging.Frontiers in genetics · 2021Review
- Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS Heterozygotes.Journal of Alzheimer's disease : JAD · 2021Article
- 547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates.Genome biology · 2019Article
- Epigenetics in Alzheimer's Disease: Perspective of DNA Methylation.Molecular neurobiology · 2018Review
- Disability Rises Gradually for a Cohort of Older Americans.The journals of gerontology. Series B, Psychological sciences and social sciences · 2017Article
- Distinct epigenomes in CD4Scientific reports · 2016Article
- PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study.Rejuvenation research · 2014Article
- De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus.Frontiers in cellular neuroscience · 2014Article
- Expression of calpain-calpastatin system (CCS) member proteins in human lymphocytes of young and elderly individuals; pilot baseline data for the CALPACENT project.Immunity & ageing : I & A · 2013Article
- Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes.Immunity & ageing : I & A · 2013Article
- Immunosenescence, aging, and systemic lupus erythematous.Autoimmune diseases · 2013Review
- Hallmarks of human "immunosenescence": adaptation or dysregulation?Immunity & ageing : I & A · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Healthy ageing and longevity in humans result from a number of factors, including genetic background, favorable environmental and social factors and chance.In this article we aimed to overview the research on the biological basis of human healthy ageing and longevity, discussing the role of epidemiological, genetic and epigenetic factors in the variation of quality of ageing and lifespan, including the most promising candidate genes investigated so far. Moreover, we reported the methodologies applied for their identification, discussing advantages and disadvantages of the different approaches and possible solutions that can be taken to overcome them. Finally, we illustrated the recent approaches to define healthy ageing and underlined the role that the emerging field of epigenetics is gaining in the search for the determinants of healthy ageing and longevity.
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Registered trials
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