ArticleInternational journal of surgical oncology2012
Increasing Age Is Associated with Worse Prognostic Factors and Increased Distant Recurrences despite Fewer Sentinel Lymph Node Positives in Melanoma.
Article in International journal of surgical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Elevated NR2F1 underlies the persistence of invasive disease after treatment of BRAF-mutant melanoma.The Journal of clinical investigation · 2025Article
- Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma.Nature aging · 2024Article
- Rapid disease progression on immune checkpoint inhibitors in young patients with stage IV melanoma.Frontiers in medicine · 2023Article
- A combined aging and immune prognostic signature predict prognosis and responsiveness to immunotherapy in melanoma.Frontiers in pharmacology · 2022Article
- Normal Aging and Its Role in Cancer Metastasis.Cold Spring Harbor perspectives in medicine · 2020Review
- Lymph node metastasis in young and middle-aged papillary thyroid carcinoma patients: a SEER-based cohort study.BMC cancer · 2020Article
- How the ageing microenvironment influences tumour progression.Nature reviews. Cancer · 2020Review
- Something Old, Something New: The Tumor Microenvironment Comes of Age.Cancer discovery · 2019Article
- Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis.Cancer discovery · 2019Article
- Young age increases risk for lymph node positivity but decreases risk for non-small cell lung cancer death.Cancer management and research · 2018Article
- Expression patterns of CD168 correlate with the stage and grade of squamous cell carcinoma of head and neck.Molecular and clinical oncology · 2017Article
- State of melanoma: an historic overview of a field in transition.Hematology/oncology clinics of North America · 2014Review
- Age as a predictor of sentinel node metastasis among patients with localized melanoma: an inverse correlation of melanoma mortality and incidence of sentinel node metastasis among young and old patients.Annals of surgical oncology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Advanced age is associated with a poorer prognosis in patients with melanoma. Despite this established finding, a decreased incidence of positive sentinel lymph nodes (SLNs) with advancing age has paradoxically been described. Methods. Using a single-institution database of melanoma patients between 1994 and 2009, the relationship between standard clinicopathologic variables and recurrence based on age was evaluated. Results. 1244 patients who underwent successful SLN biopsies were analyzed (mean followup 80.3 months). Increasing age was independently associated with worse survival on multivariable analysis (P = 0.02). SLN status was more likely to be negative if the patient was older (P = 0.01). Conclusions. Our data supports the paradox that increasing age is associated with a lower frequency of positive-SLN biopsies despite age itself being a poor prognostic factor. We propose that age-dependent variations in the primary tumor and the patient may predispose to a hematogenous route of spread for the older population, leading to worse survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.