ArticleJournal of nutrition and metabolism2012
Pathobiochemical changes in diabetic skeletal muscle as revealed by mass-spectrometry-based proteomics.
Article in Journal of nutrition and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Evaluation of the toxicity potential of exercise and atorvastatin/metformin combination therapy on STZ-diabetic rats.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Exploration of macromolecular phenotype of human skeletal muscle in diabetes using infrared spectroscopy.Frontiers in endocrinology · 2023Article
- Glucose Levels as a Mediator of the Detrimental Effect of Abdominal Obesity on Relative Handgrip Strength in Older Adults.Journal of clinical medicine · 2020Article
- Gender-effect on the contractile properties of skeletal muscle in streptozotocin-induced diabetic rats.Journal of musculoskeletal & neuronal interactions · 2018Article
- Article
- Can a simple test of functional capacity add to the clinical assessment of diabetes?Diabetic medicine : a journal of the British Diabetic Association · 2016Article
- Introduction to personalized medicine in diabetes mellitus.Rambam Maimonides medical journal · 2014Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Insulin resistance in skeletal muscle tissues and diabetes-related muscle weakness are serious pathophysiological problems of increasing medical importance. In order to determine global changes in the protein complement of contractile tissues due to diabetes mellitus, mass-spectrometry-based proteomics has been applied to the investigation of diabetic muscle. This review summarizes the findings from recent proteomic surveys of muscle preparations from patients and established animal models of type 2 diabetes. The potential impact of novel biomarkers of diabetes, such as metabolic enzymes and molecular chaperones, is critically examined. Disease-specific signature molecules may be useful for increasing our understanding of the molecular and cellular mechanisms of insulin resistance and possibly identify new therapeutic options that counteract diabetic abnormalities in peripheral organ systems. Importantly, the biomedical establishment of biomarkers promises to accelerate the development of improved diagnostic procedures for characterizing individual stages of diabetic disease progression, including the early detection of prediabetic complications.
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Registered trials
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