ArticleTranslational neuroscience2011
Above genetics: lessons from cerebral development in autism.
Article in Translational neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Molecular Evaluation of Ex3 VNTR Polymorphism of the DRD4 Gene in Patients With Autism Spectrum Disorder.Iranian journal of child neurology · 2022Article
- mTOR signalling pathway - A root cause for idiopathic autism?BMB reports · 2019Review
- Systematic reconstruction of autism biology from massive genetic mutation profiles.Science advances · 2018Article
- Epigenetic regulation of RELN and GAD1 in the frontal cortex (FC) of autism spectrum disorder (ASD) subjects.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2017Article
- Imaging genetics in neurodevelopmental psychopathology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.eLife · 2017Article
- Merging data from genetic and epigenetic approaches to better understand autistic spectrum disorder.Epigenomics · 2016Article
- Does Rubella Cause Autism: A 2015 Reappraisal?Frontiers in human neuroscience · 2016Review
- Defining Precision Medicine Approaches to Autism Spectrum Disorders: Concepts and Challenges.Frontiers in psychiatry · 2016Article
- Are Molecules Involved in Neuritogenesis and Axon Guidance Related to Autism Pathogenesis?Neuromolecular medicine · 2015Review
- Is birth a critical period in the pathogenesis of autism spectrum disorders?Nature reviews. Neuroscience · 2015Review
- Elevated fetal steroidogenic activity in autism.Molecular psychiatry · 2015Article
- Autism as a sequence: from heterochronic germinal cell divisions to abnormalities of cell migration and cortical dysplasias.Medical hypotheses · 2014Article
- The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease.Frontiers in synaptic neuroscience · 2014Review
- Article
- Association analysis of two single-nucleotide polymorphisms of the RELN gene with autism in the South African population.Genetic testing and molecular biomarkers · 2013Article
- General developmental health in the VPA-rat model of autism.Frontiers in behavioral neuroscience · 2013Article
- Spherical harmonic analysis of cortical complexity in autism and dyslexia.Translational neuroscience · 2012Article
- Age dependent forebrain structural changes in mice deficient in the autism associated gene Met tyrosine kinase.NeuroImage. Clinical · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
While a distinct minicolumnar phenotype seems to be an underlying factor in a significant portion of cases of autism, great attention is being paid not only to genetics but to epigenetic factors which may lead to development of the conditions. Here we discuss the indivisible role the molecular environment plays in cellular function, particularly the pivotal position which the transcription factor and adhesion molecule, β-catenin, occupies in cellular growth. In addition, the learning environment is not only integral to postnatal plasticity, but the prenatal environment plays a vital role during corticogenesis, neuritogenesis, and synaptogenesis as well. To illustrate these points in the case of autism, we review important findings in genetics studies (e.g., PTEN, TSC1/2, FMRP, MeCP2, Neurexin-Neuroligin) and known epigenetic factors (e.g., valproic acid, estrogen, immune system, ultrasound) which may predispose towards the minicolumnar and connectivity patterns seen in the conditions, showing how one-gene mutational syndromes and exposure to certain CNS teratogens may ultimately lead to comparable phenotypes. This in turn may shed greater light on how environment and complex genetics combinatorially give rise to a heterogenetic group of conditions such as autism.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.