ArticleCellular and molecular bioengineering2012
Modeling nuclear blebs in a nucleoskeleton of independent filament networks.
Article in Cellular and molecular bioengineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Decreased DNA density is a better indicator of a nuclear bleb than lamin B loss.Journal of cell science · 2025Article
- DNA density is a better indicator of a nuclear bleb than lamin B loss.bioRxiv : the preprint server for biology · 2024Article
- Transcription inhibition suppresses nuclear blebbing and rupture independently of nuclear rigidity.Journal of cell science · 2023Article
- 3D photopolymerized microstructured scaffolds influence nuclear deformation, nucleo/cytoskeletal protein organization, and gene regulation in mesenchymal stem cells.APL bioengineering · 2023Article
- Modelling Nuclear Morphology and Shape Transformation: A Review.Membranes · 2021Review
- Lamin microaggregates lead to altered mechanotransmission in progerin-expressing cells.Nucleus (Austin, Tex.) · 2020Article
- Review
- Chromatin and Cytoskeletal Tethering Determine Nuclear Morphology in Progerin-Expressing Cells.Biophysical journal · 2020Article
- Chromatin's physical properties shape the nucleus and its functions.Current opinion in cell biology · 2019Review
- Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins.Molecular biology of the cell · 2018Article
- Mechanics and Buckling of Biopolymeric Shells and Cell Nuclei.Biophysical journal · 2017Article
- Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus.Molecular biology of the cell · 2017Article
- Cytoskeletal tension induces the polarized architecture of the nucleus.Biomaterials · 2015Article
- Sizing and shaping the nucleus: mechanisms and significance.Current opinion in cell biology · 2014Review
- Mechanical model of blebbing in nuclear lamin meshworks.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Chromatin rigidity provides mechanical and genome protection.Mutation researchReview
- Nuclear mechanics: lamin webs and pathological blebs.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Correlations between altered nuclear shape and disease are empirically observed, but the causes of nuclear dysmorphisms are poorly understood. The nucleoskeleton, which provides the majority of the mechanical stability of the nucleus, is composed primarily of intermediate filaments of lamin proteins. The nucleoskeleton forms a mostly-planar network between the inner nuclear membrane and chromatin. It is unclear if blebs and larger scale changes in nuclear morphology are consequences of reorganization of the nucleoskeleton alone or of other cellular processes. To test this, we computationally recapitulate the lamina network using a mechanical network model created as a network of Hookean springs. A- and B-type lamin filaments were distributed over a spherical surface into distinct networks linked to one another by lamin-associated proteins. Iterative force-based adjustment of the network structure, together with a stochastically modified Bell model of bond breakage and formation, simulates nucleoskeleton reorganization with blebs. The rate of bleb retraction into the nucleus depends on both initial size of the bleb and number of networks being deformed. Our results show that induced blebs are more stable when only one filament component is deformed or when the networks have no interconnections. Also, the kinetics of retraction is influenced by the composition of the bleb. These results match with our experiments and others.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.