ArticleJournal of tropical medicine2012
Therapy of chagas disease: implications for levels of prevention.
Article in Journal of tropical medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Pooled it
- ELISA F29 -A therapeutic efficacy biomarker in Chagas disease: Evaluation in pediatric patients treated with nifurtimox and followed for 4 years post-treatment.PLoS neglected tropical diseases · 2023Trial
- Efficacy and Safety of Nifurtimox in Pediatric Patients with Chagas Disease: Results at 4-Year Follow-Up in a Prospective, Historically Controlled Study (CHICO SECURE).Antimicrobial agents and chemotherapy · 2023Trial
- Electrocardiographic Abnormalities and Treatment with Benznidazole among Children with Chronic Infection by Trypanosoma cruzi: A Retrospective Cohort Study.PLoS neglected tropical diseases · 2016Trial
- Chagasic Esophagopathy With Achalasia and Megaesophagus: A Case Report.Case reports in infectious diseases · 2026Article
- Article
- Analysis of the Chagas disease situation in Japan: a cross sectional study and cost-effectiveness analysis of a Chagas disease screening program.The Lancet regional health. Western Pacific · 2023Article
- Laboratory diagnosis ofFrontiers in parasitology · 2023Review
- Article
- Review of American Trypanosomiasis in Southern Mexico Highlights Opportunity for Surveillance Research to Advance Control Through the One Health Approach.Frontiers in public health · 2022Article
- Chagas disease control-surveillance in the Americas: the multinational initiatives and the practical impossibility of interrupting vector-borne Trypanosoma cruzi transmission.Memorias do Instituto Oswaldo Cruz · 2022Article
- Serological response to nifurtimox in adult patients with chronic Chagas disease: An observational comparative study in Argentina.PLoS neglected tropical diseases · 2021Observational
- Prospective multicenter evaluation of real time PCR Kit prototype for early diagnosis of congenital Chagas disease.EBioMedicine · 2021Article
- Rapid Diagnostic Tests for Trypanosoma cruzi Infection: Field Evaluation of Two Registered Kits in a Region of Endemicity and a Region of Nonendemicity in Argentina.Journal of clinical microbiology · 2020Article
- Treatment of Chagas Disease in the United States.Current treatment options in infectious diseases · 2018Review
- [Strategy to improve access to etiological treatment of Chagas disease at the first level of care in Argentina].Revista panamericana de salud publica = Pan American journal of public health · 2017Article
- Integrated control of Chagas disease for its elimination as public health problem--a review.Memorias do Instituto Oswaldo Cruz · 2015Article
- Trypanocide treatment of women infected with Trypanosoma cruzi and its effect on preventing congenital Chagas.PLoS neglected tropical diseases · 2014Observational
- Mother-to-Child Transmission of Trypanosoma cruzi.Journal of the Pediatric Infectious Diseases Society · 2014Article
- Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development.Scientific reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper reviews the evidence supporting the use of etiological treatment for Chagas disease that has changed the standard of care for patients with Trypanosoma cruzi infection in the last decades. Implications of this evidence on different levels of prevention as well as gaps in current knowledge are also discussed. In this regard, etiological treatment has shown to be beneficial as an intervention for secondary prevention to successfully cure the infection or to delay, reduce, or prevent the progression to disease, and as primary disease prevention by breaking the chain of transmission. Timely diagnosis during initial stages would allow for the prescription of appropriate therapies mainly in the primary health care system thus improving chances for a better quality of life. Based on current evidence, etiological treatment has to be considered as an essential public health strategy useful to reduce disease burden and to eliminate Chagas disease altogether.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.