ArticleJournal of toxicology2012
MicroRNAs in Neurotoxicity.
Article in Journal of toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The cellular model for Alzheimer's disease research: PC12 cells.Frontiers in molecular neuroscience · 2022Pooled it
- Acute Spinal Cord Injury: A Systematic Review Investigating miRNA Families Involved.International journal of molecular sciences · 2019Pooled it
- Review
- MicroRNA-219 in the central nervous system: a potential theranostic approach.Research in pharmaceutical sciences · 2024Review
- MicroRNAs-Based Theranostics against Anesthetic-Induced Neurotoxicity.Pharmaceutics · 2023Review
- Profiling Secreted miRNA Biomarkers of Chemical-Induced Neurodegeneration in Human iPSC-Derived Neurons.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- Phenotypically Anchored mRNA and miRNA Expression Profiling in Zebrafish Reveals Flame Retardant Chemical Toxicity Networks.Frontiers in cell and developmental biology · 2021Article
- Upregulation of miR-215 attenuates propofol-induced apoptosis and oxidative stress in developing neurons by targeting LATS2.Molecular medicine (Cambridge, Mass.) · 2020Article
- The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia.Cellular and molecular neurobiology · 2019Review
- MicroRNA-140 inhibits tumor progression in nasopharyngeal carcinoma by targeting CXCR4.International journal of clinical and experimental pathology · 2017Article
- Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism.International journal of genomics · 2017Review
- Modulation of miRNA-155 alters manganese nanoparticle-induced inflammatory response.Toxicology research · 2016Article
- Alteration of microRNA expressions in the pons and medulla in rats after 3,3'-iminodipropionitrile administration.Journal of toxicologic pathology · 2016Article
- Down-regulation of microRNA-21 is involved in the propofol-induced neurotoxicity observed in human stem cell-derived neurons.Anesthesiology · 2014Article
- The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- MicroRNA dysregulation in spinal cord injury: causes, consequences and therapeutics.Frontiers in cellular neuroscience · 2014Review
- Article
- MicroRNA profiling as tool for in vitro developmental neurotoxicity testing: the case of sodium valproate.PloS one · 2014Article
- Specific Roles of MicroRNAs in Their Interactions with Environmental Factors.Journal of nucleic acids · 2012Article
- Lack of miRNA Misregulation at Early Pathological Stages in Drosophila Neurodegenerative Disease Models.Frontiers in genetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs are gaining importance as regulators of gene expression with the capability to fine-tune and modulate cellular events. The complex network with their selective targets (mRNAs/genes) pave way for regulation of many physiological processes. Dysregulation of normal neuronal activities could result in accumulation of substances that are detrimental to neuronal functions and subsequently result in neurotoxicity. Neurotoxicity-mediated pathophysiological conditions could then manifest as diseases or disabilities like Parkinson's and Alzheimer's which have debilitating implications. Such toxicity can be a result of individuals predisposed due to genetic inheritance or from other sources such as brain tumours. Neurotoxicity can also be brought about by external agents like drugs and alcohol as well as brain injury with miRNAs playing a pivotal role in diseases. It is therefore vital to understand the expression of these microRNAs and their impact on neuronal activities. In this paper, we discuss some of the neuronal pathophysiological conditions that could be caused by dysregulated microRNAs.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.