ArticleJournal of toxicology2012
The adverse effects of air pollution on the nervous system.
Article in Journal of toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 267 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
267 citing papers in PubMed, 9 syntheses or guidelines pooled it, 706 citations in OpenAlex.
- Airborne pollutants and risk of neurodegenerative diseases: a global systematic review and meta-analysis.Alzheimer's research & therapy · 2026Pooled it
- Small extracellular vesicles: connecting early life exposure outcomes to air pollution during pregnancy to early childhood health.Environmental health : a global access science source · 2025Pooled it
- A systematic review of air pollution exposure and brain structure and function during development.Environmental research · 2025Pooled it
- Effect of air pollutants particulate matter (PMScientific reports · 2024Pooled it
- The Relationship between Air Pollution and Brain Cancer: A Systematic Review and Meta-Analysis.Annals of global health · 2023Pooled it
- Urbanization, air pollution, and water pollution: Identification of potential environmental risk factors associated with amyotrophic lateral sclerosis using systematic reviews.Frontiers in neurology · 2023Pooled it
- Air pollution, depressive and anxiety disorders, and brain effects: A systematic review.Neurotoxicology · 2022Pooled it
- Does protracted radon exposure play a role in the development of dementia?Environmental research · 2022Pooled it
- Exposure to air pollution and cognitive impairment risk: a meta-analysis of longitudinal cohort studies with dose-response analysis.Journal of global health · 2020Pooled it
- Updated Knowledge on Radon Exposure: Quantification Methods, Health Effects, and Molecular Mechanisms.Environment & health (Washington, D.C.) · 2026Review
- Air pollution and cognitive outcomes in older adults: a systematic review.Reviews on environmental health · 2026Review
- Impact of Environmental Exposure on Infant Sleep : The Exposome Approach.Journal of sleep research · 2026Review
- Real-time record of particulate matter along traffic roads and health risk assessment.Environmental science and pollution research international · 2026Article
- A critical review of potential modifiers of air pollutant associations with dementia and related outcomes.Neurotoxicology · 2026Review
- Dynamics of neutrophilia at the neurovascular unit arising from repeated pulmonary inflammation.Journal of neuroinflammation · 2026Article
- The sex-specific association between long-term PM2.5 exposure and incident dementia in community-dwelling older adults in Australia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Long-Term Exposure to Air Pollution and Risk and Prognosis of Motor Neuron Disease.JAMA neurology · 2026Article
- Review
- Childhood Opportunity Index 2.0 and Cognition via the NIH Toolbox.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Impact of air pollution on mental health in bangladesh: a comparison between Dhaka and Rajshahi.Scientific reports · 2026Article
207 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to ambient air pollution is a serious and common public health concern associated with growing morbidity and mortality worldwide. In the last decades, the adverse effects of air pollution on the pulmonary and cardiovascular systems have been well established in a series of major epidemiological and observational studies. In the recent past, air pollution has also been associated with diseases of the central nervous system (CNS), including stroke, Alzheimer's disease, Parkinson's disease, and neurodevelopmental disorders. It has been demonstrated that various components of air pollution, such as nanosized particles, can easily translocate to the CNS where they can activate innate immune responses. Furthermore, systemic inflammation arising from the pulmonary or cardiovascular system can affect CNS health. Despite intense studies on the health effects of ambient air pollution, the underlying molecular mechanisms of susceptibility and disease remain largely elusive. However, emerging evidence suggests that air pollution-induced neuroinflammation, oxidative stress, microglial activation, cerebrovascular dysfunction, and alterations in the blood-brain barrier contribute to CNS pathology. A better understanding of the mediators and mechanisms will enable the development of new strategies to protect individuals at risk and to reduce detrimental effects of air pollution on the nervous system and mental health.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.