ArticleRadiology2012
High-resolution 3D MR microangiography of the rat ocular circulation.
Article in Radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- In vivo MRI evaluation of early postnatal development in normal and impaired rat eyes.Scientific reports · 2021Article
- High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice.Biomedical optics express · 2021Article
- Rapamycin Increases Collateral Circulation in Rodent Brain after Focal Ischemia as detected by Multiple Modality Dynamic Imaging.Theranostics · 2019Article
- Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography.Frontiers in aging neuroscience · 2017Article
- MRI of rod cell compartment-specific function in disease and treatment in vivo.Progress in retinal and eye research · 2016Review
- In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury With Multimodal MRI and OCT.Investigative ophthalmology & visual science · 2015Article
- Comparison of retinal and cerebral blood flow between continuous arterial spin labeling MRI and fluorescent microsphere techniques.Journal of magnetic resonance imaging : JMRI · 2014Article
- In vivo assessment of aqueous humor dynamics upon chronic ocular hypertension and hypotensive drug treatment using gadolinium-enhanced MRI.Investigative ophthalmology & visual science · 2014Article
- Magnetic resonance imaging of the retina: from mice to men.Magnetic resonance in medicine · 2014Review
- Functional hyperemia and mechanisms of neurovascular coupling in the retinal vasculature.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Review
- MRI biomarkers for evaluation of treatment efficacy in preclinical diabetic retinopathy.Expert opinion on medical diagnostics · 2013Review
- MRI study of cerebral, retinal and choroidal blood flow responses to acute hypertension.Experimental eye research · 2013Article
- Ultra high-resolution fMRI and electrophysiology of the rat primary somatosensory cortex.NeuroImage · 2013Article
- Decreased retinal-choroidal blood flow in retinitis pigmentosa as measured by MRI.Documenta ophthalmologica. Advances in ophthalmology · 2013Article
- Quantitative retinal and choroidal blood flow during light, dark adaptation and flicker light stimulation in rats using fluorescent microspheres.Current eye research · 2013Article
- Surgery-related thrombosis critically affects the brain infarct volume in mice following transient middle cerebral artery occlusion.PloS one · 2013Article
- Review: magnetic resonance imaging techniques in ophthalmology.Molecular vision · 2012Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo develop high-spatial-resolution magnetic resonance (MR) microangiography techniques to image the rat ocular circulation. MATERIALS AND
methodsAnimal experiments were performed with institutional Animal Care Committee approval. MR microangiography (resolution, 84×84×84 μm or 42×42×84 μm) of the rat eye (eight rats) was performed by using a custom-made small circular surface coil with an 11.7-T MR unit before and after monocrystalline iron oxide nanoparticle (MION) injection. MR microangiography measurements were made during air, oxygen, and carbogen inhalation. From three-dimensional MR microangiography, the retina was virtually flattened to enable en face views of various retinal depths, including the retinal and choroidal vascular layers. Signal intensity changes within the retinal or choroidal arteries and veins associated with gas challenges were analyzed. Statistical analysis was performed by using paired t tests, with P<.05 considered to indicate a significant difference. Bonferroni correction was used to adjust for multiple comparisons.
resultsThe central retinal artery, long posterior ciliary arteries, and choroidal vasculature could be distinguished on MR microangiograms of the eye. With MR microangiography, retinal arteries and veins could be distinguished on the basis of blood oxygen level-dependent contrast. Carbogen inhalation-enhanced MR microangiography signal intensity in both the retina (P=.001) and choroid (P=.027) compared with oxygen inhalation. Carbogen inhalation showed significantly higher signal intensity changes in the retinal arteries (P=.001, compared with oxygen inhalation), but not in the veins (P=.549). With MION administration, MR microangiography depicted retinal arterial vasoconstriction when the animals were breathing oxygen (P=.02, compared with animals breathing air).
conclusionMR microangiography of the eye allows depth-resolved imaging of small angiographic details of the ocular circulation. This approach may prove useful in studying microvascular pathologic findings and neurovascular dysfunction in the eye and retina.
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Registered trials
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