ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2012
Impact of USA300 methicillin-resistant Staphylococcus aureus on clinical outcomes of patients with pneumonia or central line-associated bloodstream infections.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Mortality among patients with methicillin-resistant Staphylococcus aureus USA300 versus non-USA300 invasive infections: a meta-analysis.Infection control and hospital epidemiology · 2014Pooled it
- Post-discharge decolonization of patients harboring methicillin-resistantInfection control and hospital epidemiology · 2023Trial
- Development and validation of a prognostic model incorporating the blood urea nitrogen-to-albumin ratio for predicting mortality in methicillin-resistant Staphylococcus aureus bloodstream infection.BMC infectious diseases · 2026Article
- Epidemiologic and Clinical Divergence of MRSA USA100 and USA300 in the United States.Antibiotics (Basel, Switzerland) · 2026Article
- The dltC gene contributes to polyhexamethylene biguanide resistance inFrontiers in microbiology · 2025Article
- Article
- Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing.Frontiers in cellular and infection microbiology · 2023Review
- Daptomycin versus Vancomycin for the Treatment of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Review
- Glycosylation-dependent opsonophagocytic activity of staphylococcal protein A antibodies.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Prevalence and Therapies of Antibiotic-Resistance inFrontiers in cellular and infection microbiology · 2020Review
- Changing Characteristics of Staphylococcus aureus Bacteremia: Results From a 21-Year, Prospective, Longitudinal Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Draft Genome Sequence of USA100 Methicillin-ResistantGenome announcements · 2018Article
- Effect of far ultraviolet light emitted from an optical diffuser on methicillin-resistant Staphylococcus aureus in vitro.PloS one · 2018Article
- Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light.Radiation research · 2017Article
- Outcomes and Treatment of Chronic Methicillin-Resistant Staphylococcus aureus Differs by Staphylococcal Cassette Chromosome mec (SCCmec) Type in Children With Cystic Fibrosis.Journal of the Pediatric Infectious Diseases Society · 2015Observational
- Methicillin-resistant Staphylococcus aureus colonization among pediatric health care workers from different outpatient settings.American journal of infection control · 2013Article
- Post-discharge mortality in patients hospitalized with MRSA infection and/or colonization.Epidemiology and infection · 2013Article
- Predictors of hospitals with endemic community-associated methicillin-resistant Staphylococcus aureus.Infection control and hospital epidemiology · 2013Article
- Persistent nasal methicillin-resistant staphylococcus aureus carriage in hemodialysis outpatients: a predictor of worse outcome.BMC nephrology · 2013Article
- 207-nm UV light - a promising tool for safe low-cost reduction of surgical site infections. I: in vitro studies.PloS one · 2013Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundThe USA300 methicillin-resistant Staphylococcus aureus (MRSA) strain, which initially emerged as a cause of community-associated infections, has recently become an important pathogen in healthcare-associated infections (HAIs). However, its impact on patient outcomes has not been well studied. We evaluated patients with invasive MRSA infections to assess differences in outcomes between infections caused by USA100 and those caused by USA300.
methodsPopulation-based data for invasive MRSA infections were used to identify 2 cohorts: (1) nondialysis patients with central line-associated bloodstream infections (CLABSIs) and (2) patients with community-onset pneumonia (PNEUMO) during 2005-2007 from 6 US metropolitan areas. Medical records of patients with confirmed MRSA USA100 or USA300 infection were reviewed. Logistic regression and, when appropriate, survival analysis was performed to evaluate mortality, early and late complications, and length of stay.
resultsA total of 236 and 100 patients were included in the CLABSI and PNEUMO cohorts, respectively. USA300 was the only independent predictor of early complications for PNEUMO patients (odds ratio [OR], 2.6; P = .02). Independent predictors of CLABSI late complications included intensive care unit (ICU) admission before MRSA culture (adjusted OR [AOR], 2.1; P= .01) and Charlson comorbidity index (AOR, 2.6; P = .003), but not strain type. PNEUMO patients were significantly more likely to die if they were older (P = .02), black (P < .001), or infected with USA100 strain (P = .02), whereas those with CLABSI were more likely to die if they were older (P < .001), had comorbidities (P < .001), or had an ICU admission before MRSA culture (P = .001).
conclusionsUSA300 was associated with early complications in PNEUMO patients. However, it was not associated with mortality for either PNEUMO or CLABSI patients. Concerns regarding higher mortality from HAIs caused by USA300 may not be warranted.
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