ReviewAmerican journal of physiology. Heart and circulatory physiology2012
Post-translational modification of cardiac proteasomes: functional delineation enabled by proteomics.
Review in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Integrative Multi-PTM Proteomics Reveals Dynamic Global, Redox, Phosphorylation, and Acetylation Regulation in Cytokine-Treated Pancreatic Beta Cells.Molecular & cellular proteomics : MCP · 2024Article
- Protein homeostasis in the aged and diseased heart.The journal of cardiovascular aging · 2023Article
- Proteasome Complexes and Their Heterogeneity in Colorectal, Breast and Pancreatic Cancers.Journal of Cancer · 2021Article
- Targeting Mitochondria during Cold Storage to Maintain Proteasome Function and Improve Renal Outcome after Transplantation.International journal of molecular sciences · 2020Review
- Quantitative proteomic and phosphoproteomic profiling of ischemic myocardial stunning in swine.American journal of physiology. Heart and circulatory physiology · 2020Article
- Phosphorylation Modifications Regulating Cardiac Protein Quality Control Mechanisms.Frontiers in physiology · 2020Review
- A Cycle of Altered Proteasome and Reactive Oxygen Species Production in Renal Proximal Tubular Cells.Toxicology and forensic medicine : open journal · 2019Article
- Renal cold storage followed by transplantation impairs proteasome function and mitochondrial protein homeostasis.American journal of physiology. Renal physiology · 2019Article
- Ubiquitin and Ubiquitin-like proteins in cardiac disease and protection.Current drug targets · 2018Review
- Regulating protein breakdown through proteasome phosphorylation.The Biochemical journal · 2017Review
- Reversible phosphorylation of the 26S proteasome.Protein & cell · 2017Review
- Proteasome Activity Profiling Uncovers Alteration of Catalytic β2 and β5 Subunits of the Stress-Induced Proteasome during Salinity Stress in Tomato Roots.Frontiers in plant science · 2017Article
- Characterizing the dynamics of proteasome complexes by proteomics approaches.Antioxidants & redox signaling · 2014Review
- Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes.Circulation research · 2014Article
- Lysine ubiquitination and acetylation of human cardiac 20S proteasomes.Proteomics. Clinical applications · 2014Article
- Proteasomal and lysosomal protein degradation and heart disease.Journal of molecular and cellular cardiology · 2014Review
- Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond.Journal of molecular and cellular cardiology · 2014Review
- Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner.Journal of molecular and cellular cardiology · 2014Article
- Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins.Circulation · 2013Article
- The ubiquitin proteasome system and myocardial ischemia.American journal of physiology. Heart and circulatory physiology · 2013Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Proteasomes are ubiquitously expressed multicatalytic complexes that serve as key regulators of protein homeostasis. There are several lines of evidence indicating that proteasomes exist in heterogeneous subpopulations in cardiac muscle, differentiated, in part, by post-translational modifications (PTMs). PTMs regulate numerous facets of proteasome function, including catalytic activities, complex assembly, interactions with associating partners, subcellular localization, substrate preference, and complex turnover. Classical technologies used to identify PTMs on proteasomes have lacked the ability to determine site specificity, quantify stoichiometry, and perform large-scale, multi-PTM analysis. Recent advancements in proteomic technologies have largely overcome these limitations. We present here a discussion on the importance of PTMs in modulating proteasome function in cardiac physiology and pathophysiology, followed by the presentation of a state-of-the-art proteomic workflow for identifying and quantifying PTMs of cardiac proteasomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.