ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2012
Acute demyelinating lesions with restricted diffusion in multiple sclerosis.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Expert Panel Consensus Guidelines of the German Society of Neuroradiology on the Use of Magnetic Resonance Imaging in the Diagnosis and Monitoring of Multiple Sclerosis.Clinical neuroradiology · 2026Guideline
- Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis-clinical implementation in the diagnostic process.Nature reviews. Neurology · 2015Guideline
- Recalibration and external validation of vascular risk calculators for multiple sclerosis: A population-based study using CPRD data in England, 1987-2023.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Conventional and Advanced Magnetic Resonance Imaging Biomarkers of Multiple Sclerosis in the Brain.Cureus · 2025Review
- The Value of Using Quantitative MRI based on Synthetic Acquisition and Apparent Diffusion Coefficient to Monitor Multiple Sclerosis Lesion Activity.Current medical imaging · 2025Article
- Use of gadolinium-based contrast agents in multiple sclerosis: a review by the ESMRMB-GREC and ESNR Multiple Sclerosis Working Group.European radiology · 2024Review
- Differential imaging of atypical demyelinating lesions of the central nervous system.La Radiologia medica · 2021Review
- Paroxysmal Symptoms in Multiple Sclerosis-A Review of the Literature.Journal of clinical medicine · 2020Review
- Is It Possible to Discriminate Active MS Lesions with Diffusion Weighted Imaging?The Eurasian journal of medicine · 2019Article
- Rebound After Fingolimod and a Single Daclizumab Injection in a Patient Retrospectively Diagnosed With NMO Spectrum Disorder-MRI Apparent Diffusion Coefficient Maps in Differential Diagnosis of Demyelinating CNS Disorders.Frontiers in neurology · 2018Article
- Comparison of diffusion-weighted imaging and enhanced T1-weighted sequencing in patients with multiple sclerosis.The neuroradiology journal · 2017Article
- Fulminant tumefactive multiple sclerosis in pregnancy.BMJ case reports · 2017Article
- Diffusion Weighted Imaging in Acute Attacks of Multiple Sclerosis.Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society · 2016Article
- A semi-automated measuring system of brain diffusion and perfusion magnetic resonance imaging abnormalities in patients with multiple sclerosis based on the integration of coregistration and tissue segmentation procedures.BMC medical imaging · 2016Article
- Therapeutic management of severe relapses in multiple sclerosis.Current treatment options in neurology · 2015Article
- Weekly multimodal MRI follow-up of two multiple sclerosis active lesions presenting a transient decrease in ADC.Brain and behavior · 2015Article
- Hypoperfusion and T1-hypointense lesions in white matter in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2014Article
- Utility of proton MR spectroscopy for differentiating typical and atypical primary central nervous system lymphomas from tumefactive demyelinating lesions.AJNR. American journal of neuroradiology · 2014Article
- "Dazed and diffused": making sense of diffusion abnormalities in neurologic pathologies.The British journal of radiology · 2013Review
- Are Periventricular Lesions Specific for Multiple Sclerosis?Journal of neurology & neurophysiology · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
BACKGROUND AND
objectivesIt is widely accepted that typical acute demyelinating lesions in relapsing-remitting multiple sclerosis (RRMS) exhibit vasogenic edema with increased diffusion, as demonstrated by an increased apparent diffusion coefficient on MRI. In contrast, acute ischemic lesions demonstrate cytotoxic edema with restricted diffusion. Recent reports have documented selected cases of acute demyelinating lesions exhibiting restricted diffusion (ADLRD) in MS. We aimed to assess the morphologies, distributions, signal characteristics and changes over time of nine ADLRD. An additional goal was to obtain clinical correlations and relate our findings to all previously published case reports describing ADLRD.
methodsA retrospective case series study was performed at two academic centers. MRI characteristics of nine ADLRD found in six RRMS patients were compared with typical active symptomatic contrast-enhancing lesions with increased or normal diffusion in control RRMS patients.
resultsThe average size of ADLRD was not significantly different from typical lesions. A periventricular location and faint signal on T2-weighted images were significantly more common for ADLRD compared with typical lesions. Two patients with ADLRD on initial MRI exhibited new ADLRD on their follow up scans.
conclusionOur results and review of prior published cases suggest that ADLRD represent a new variant of MS lesion. The restricted diffusion that is a characteristic of ADLRD on MRI is a new challenge in the differential diagnosis of stroke in young adults. The pathogenesis of ADLRD remains to be understood.
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