Evidence map›Paper›PMID 22523062›Full record

ArticleThe Journal of clinical investigation2012

NADPH oxidase regulates efficacy of vaccination in aspergillosis.

George S Deepe

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

George S DeepeDivision of Infectious Diseases, University of Cincinnati College of Medicine, and the Veterans Affairs Hospital, Cincinnati, Ohio 45267-0560, USA. george.deepe@uc.edu
University of Cincinnati Medical Center · US

Funding

Immunopathogenesis in HistoplasmosisR01AI073337 · NIAID · UNIVERSITY OF CINCINNATI · PI DEEPE, GEORGE S. · 2008 to 2012
$2.0M
Chemokine-Cytokine Nexus in Fungal ImmunityR01AI083313 · NIAID · UNIVERSITY OF CINCINNATI · PI DEEPE, GEORGE S. · 2010 to 2014
$1.9M
Myeloid Cell KLF2 and IL-4 in HistoplasmosisR21AI096823 · NIAID · UNIVERSITY OF CINCINNATI · PI DEEPE, GEORGE S. · 2011 to 2012
$443k
Chemokine-Cytokine Nexus in Fungal ImmunityR56AI083313 · NIAID · UNIVERSITY OF CINCINNATI · PI DEEPE, GEORGE S. · 2009 to 2009
$294k
Molecular and Cellular Determinants of Immunity to HistoplasmosisI01BX000717 · VA · CINCINNATI VA MEDICAL CENTER RESEARCH · PI DEEPE, GEORGE S. · 2011 to 2017
–
BLRD VA I01 BX000717NIAID NIH HHS AI073337NIAID NIH HHS AI083313NIAID NIH HHS AI096823NIAID NIH HHS R01 AI073337NIAID NIH HHS R01 AI083313NIAID NIH HHS R21 AI096823NIAID NIH HHS R56 AI083313
6 · The paper itself

Abstract

Invasive aspergillosis is often a consequence of immune suppression, and accumulating evidence points to a role for adaptive immunity. Hence, it may be possible to manipulate the adaptive immune system to enhance protective immunity in at-risk individuals. In this issue of the JCI, De Luca and colleagues describe the ontogeny of adaptive immune responses to murine aspergillosis infection in relation to vaccination. Their thought-provoking findings reveal the complexities of vaccine-induced immunity and could be used to improve vaccine efficacy.

Indexed as

Cross-PrimingVaccinationAnimalsAntigens, FungalFemaleGranulomatous Disease, ChronicAntigens, Fungal

Identifiers

PMID22523062
PMCPMC3337002
OpenAlexW2055086849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.