Evidence map›Paper›PMID 22522927›Full record

Trial reportNature2012

Selective cortical representation of attended speaker in multi-talker speech perception.

Nima Mesgarani, Edward F Chang

Abstract readClinical Trial
In one paragraph

Trial report in Nature, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 462 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
462citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

462 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Longitudinal adaptations in neural and behavioral systems following hearing restoration using cochlear implants.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  6. [Dual-stream temporal-frequency convolutional network with additive attention for auditory attention decoding].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Article
  7. Article
  8. From Selective Listening to Brain-Controlled Hearing: A Perspective on the Future of Auditory Technology.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Review
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402 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nima MesgaraniDepartments of Neurological Surgery and Physiology, UCSF Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA.
Edward F Chang

Funding

Functional organization of the superior temporal gyrus for speech perceptionR01DC012379 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Edward Chang · 2012 to 2026
$8.3M
Neocortical Mechanisms of Categorical Speech PerceptionR00NS065120 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHANG, EDWARD · 2010 to 2012
$729k
NIDCD NIH HHS R01 DC012379NIDCD NIH HHS R01-DC012379NIH HHS DP2-OD00862NINDS NIH HHS R00 NS065120NINDS NIH HHS R00-NS065120
6 · The paper itself

Abstract

Humans possess a remarkable ability to attend to a single speaker's voice in a multi-talker background. How the auditory system manages to extract intelligible speech under such acoustically complex and adverse listening conditions is not known, and, indeed, it is not clear how attended speech is internally represented. Here, using multi-electrode surface recordings from the cortex of subjects engaged in a listening task with two simultaneous speakers, we demonstrate that population responses in non-primary human auditory cortex encode critical features of attended speech: speech spectrograms reconstructed based on cortical responses to the mixture of speakers reveal the salient spectral and temporal features of the attended speaker, as if subjects were listening to that speaker alone. A simple classifier trained solely on examples of single speakers can decode both attended words and speaker identity. We find that task performance is well predicted by a rapid increase in attention-modulated neural selectivity across both single-electrode and population-level cortical responses. These findings demonstrate that the cortical representation of speech does not merely reflect the external acoustic environment, but instead gives rise to the perceptual aspects relevant for the listener's intended goal.

Indexed as

Acoustic StimulationSpeechAcousticsAttentionAuditory CortexElectrodesFemaleHumansLanguageMaleModels, NeurologicalNoiseSound SpectrographySpeech Perception

Identifiers

PMID22522927
PMCPMC3870007

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.