ArticleEpigenetics2012
Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life.
Article in Epigenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epigenetics and human obesity.International journal of obesity (2005) · 2015Pooled it
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- Prenatal exposure to environmental phenols and phthalates and altered patterns of DNA methylation in childhood.Environment international · 2024Article
- Individual longitudinal changes in DNA-methylome identify signatures of early-life adversity and correlate with later outcome.Neurobiology of stress · 2024Article
- Impact of intrauterine exposure to maternal diabetes on preterm birth: fetal DNA methylation alteration is an important mediator.Clinical epigenetics · 2023Article
- Integrative Approaches of DNA Methylation Patterns According to Age, Sex and Longitudinal Changes.Current genomics · 2023Article
- Inter-Individual Variation in DNA Methylation Patterns across Two Tissues and Leukocytes in Mature Brahman Cattle.Biology · 2023Article
- Epigenome-wide association studies: current knowledge, strategies and recommendations.Clinical epigenetics · 2021Review
- Genes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases.Pediatric pulmonology · 2021Article
- Variability of multi-omics profiles in a population-based child cohort.BMC medicine · 2021Article
- Glucocorticoid Signaling and Epigenetic Alterations in Stress-Related Disorders.International journal of molecular sciences · 2021Review
- Promoter Activity-Based Case-Control Association Study on SLC6A4 Highlighting Hypermethylation and Altered Amygdala Volume in Male Patients With Schizophrenia.Schizophrenia bulletin · 2020Article
- Differential DNA methylation profile in infants born small-for-gestational-age: association with markers of adiposity and insulin resistance from birth to age 24 months.BMJ open diabetes research & care · 2020Article
- Epigenetic Dynamics of the Infant Immune System Reveals a Tumor Necrosis Factor Superfamily Signature in Early Human Life.Epigenomes · 2020Article
- Changes of DNA methylation are associated with changes in lung function during adolescence.Respiratory research · 2020Article
- Genome-Wide DNA Methylation Patterns in Children Exposed to Nonpharmacologically Treated Prenatal Depressive Symptoms: Results From 2 Independent Cohorts.Epigenetics insights · 2020Article
- An Eight-CpG-based Methylation Classifier for Preoperative Discriminating Early and Advanced-Late Stage of Colorectal Cancer.Frontiers in genetics · 2020Article
- Epigenomics and Early Life Human Humoral Immunity: Novel Paradigms and Research Opportunities.Frontiers in immunology · 2020Review
- DNA Methylation Reorganization of Skeletal Muscle-Specific Genes in Response to Gestational Obesity.Frontiers in physiology · 2020Article
- Seasonal Variation in Genome-Wide DNA Methylation Patterns and the Onset of Seasonal Timing of Reproduction in Great Tits.Genome biology and evolution · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Prenatal development and early childhood are critical periods for establishing the tissue-specific epigenome, and may have a profound impact on health and disease in later life. However, epigenomic profiles at birth and in early childhood remain largely unexplored. The focus of this report is to examine the individual variation and longitudinal pattern of genome-wide DNA methylation levels from birth through the first two years of life in 105 Black children (59 males and 46 females) enrolled at the Boston Medical Center. We performed epigenomic mapping of cord blood at birth and venous blood samples from the same set of children within the first two years of life using Illumina Infinium Humanmethylation27 BeadChip. We observed a wide range of inter-individual variations in genome-wide methylation at each time point including lower levels at CpG islands, TSS200, 5'UTR and 1st Exon locations, but significantly higher levels in CpG shores, shelves, TSS1500, gene body and 3'UTR. We identified CpG sites with significant intra-individual longitudinal changes in the first two years of life throughout the genome. Specifically, we identified 159 CpG sites in males and 149 CpG sites in females with significant longitudinal changes defined by both statistical significance and magnitude of changes. These significant CpG sites appeared to be located within genes with important biological functions including immunity and inflammation. Further studies are needed to replicate our findings, including analysis by specific cell types, and link those individual variations and longitudinal changes with specific health outcomes in early childhood and later life.
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