ArticleOrganic & biomolecular chemistry2012
Peptides that anneal to natural collagen in vitro and ex vivo.
Article in Organic & biomolecular chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed.
- Biomimetic peptide conjugates as emerging strategies for controlled release from protein-based materials.Drug delivery · 2025Review
- Around the collagen triple helix: an introduction to studying associated genetic and acquired diseases.Matrix biology : journal of the International Society for Matrix Biology · 2025Review
- Topical Application of a Collagen Mimetic Peptide Restores Peripapillary Scleral Stiffness Reduced by Ocular Stress.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Collagen mimetic peptides as novel therapeutics for vascular disease in the central nervous system.Frontiers in neuroscience · 2025Article
- Peptidic "Molecular Beacon" for Collagen.Biomacromolecules · 2024Article
- Optimizing protein delivery rate from silk fibroin hydrogel using silk fibroin-mimetic peptides conjugation.Scientific reports · 2024Article
- Collagen in the central nervous system: contributions to neurodegeneration and promise as a therapeutic target.Molecular neurodegeneration · 2024Review
- Collagen Mimetic Peptides Promote Repair of MMP-1-Damaged Collagen in the Rodent Sclera and Optic Nerve Head.International journal of molecular sciences · 2023Article
- Detection of Pulmonary Fibrosis with a Collagen-Mimetic Peptide.ACS sensors · 2023Article
- The Chemistry and Biology of Collagen Hybridization.Journal of the American Chemical Society · 2023Review
- Recent Approaches to the Modification of Collagen Biomatrix as a Corneal Biomatrix and Its Cellular Interaction.Polymers · 2023Review
- Collagen mimetic peptide repair of the corneal nerve bed in a mouse model of dry eye disease.Frontiers in neuroscience · 2023Article
- Collagen Mimetic Peptides Promote Adherence and Migration of ARPE-19 Cells While Reducing Inflammatory and Oxidative Stress.International journal of molecular sciences · 2022Article
- Intraocular Delivery of a Collagen Mimetic Peptide Repairs Retinal Ganglion Cell Axons in Chronic and Acute Injury Models.International journal of molecular sciences · 2022Article
- Bifunctional Peptide that Anneals to Damaged Collagen and Clusters TGF-β Receptors Enhances Wound Healing.ACS chemical biology · 2022Article
- Collagen Mimetic Peptides Promote Corneal Epithelial Cell Regeneration.Frontiers in pharmacology · 2021Article
- Restoring the Extracellular Matrix: A Neuroprotective Role for Collagen Mimetic Peptides in Experimental Glaucoma.Frontiers in pharmacology · 2021Article
- Role for Cell-Surface Collagen ofACS infectious diseases · 2020Article
- Cyclic Peptide Mimetic of Damaged Collagen.Biomacromolecules · 2020Article
- Templated Collagen "Double Helices" Maintain Their Structure.Journal of the American Chemical Society · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Collagen comprises ¼ of the protein in humans and ¾ of the dry weight of human skin. Here, we implement recent discoveries about the structure and stability of the collagen triple helix to design new chemical modalities that anchor to natural collagen. The key components are collagen mimetic peptides (CMPs) that are incapable of self-assembly into homotrimeric triple helices, but are able to anneal spontaneously to natural collagen. We show that such CMPs containing 4-fluoroproline residues, in particular, bind tightly to mammalian collagen in vitro and to a mouse wound ex vivo. These synthetic peptides, coupled to dyes or growth factors, could herald a new era in assessing or treating wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.