ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2012
Comparative genome analysis of two Cryptosporidium parvum isolates with different host range.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 78 citations in OpenAlex.
- Single Oocyst Selection and Whole-Genome Amplification of Cryptosporidium parvum.Methods in molecular biology (Clifton, N.J.) · 2026Article
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- Impact of predicted microbiota tryptophanase activity on Cryptosporidium parvum proliferation.PloS one · 2025Article
- Chromosome-level genome assembly of Cryptosporidium parvum by long-read sequencing of ten oocysts.Scientific data · 2024Article
- Fecal microbiota impacts development of Cryptosporidium parvum in the mouse.Scientific reports · 2024Article
- InvestigatingInternational journal of molecular sciences · 2023Review
- High subtelomeric GC content in the genome of a zoonoticMicrobial genomics · 2023Article
- Article
- An update onJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Review
- Fully resolved assembly of Cryptosporidium parvum.GigaScience · 2022Article
- Paving the Way: Contributions of Big Data to Apicomplexan and Kinetoplastid Research.Frontiers in cellular and infection microbiology · 2022Review
- Genetic basis for virulence differences of various Cryptosporidium parvum carcinogenic isolates.Scientific reports · 2020Article
- Update on Cryptosporidium spp.: highlights from the Seventh International Giardia and Cryptosporidium Conference.Parasite (Paris, France) · 2020Review
- Comparative genomic analysis of the principalPeerJ · 2020Article
- Comparative genomics: how has it advanced our knowledge of cryptosporidiosis epidemiology?Parasitology research · 2019Review
- Whole genome sequencing of Entamoeba nuttalli reveals mammalian host-related molecular signatures and a novel octapeptide-repeat surface protein.PLoS neglected tropical diseases · 2019Article
- Patterns of protist diversity associated with raw sewage in New York City.The ISME journal · 2019Article
- Deprivation of dietary fiber enhances susceptibility of mice to cryptosporidiosis.PLoS neglected tropical diseases · 2019Article
- The transcriptome of Cryptosporidium oocysts and intracellular stages.Scientific reports · 2019Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Parasites of the genus Cryptosporidium infect the intestinal and gastric epithelium of different vertebrate species. Some of the many Cryptosporidium species described to date differ with respect to host range; whereas some species' host range appears to be narrow, others have been isolated from taxonomically unrelated vertebrates. To begin to investigate the genetic basis of Cryptosporidium host specificity, the genome of a Cryptosporidium parvum isolate belonging to a sub-specific group found exclusively in humans was sequenced and compared to the reference C. parvum genome representative of the zoonotic group. Over 12,000 single-nucleotide polymorphisms (SNPs), or 1.4 SNP per kilobase, were identified. The genome distribution of SNPs was highly heterogeneous, but non-synonymous and silent SNPs were similarly distributed. On many chromosomes, the most highly divergent regions were located near the ends. Genes in the most diverged regions were almost twice as large as the genome-wide average. Transporters, and ABC transporters in particular, were over-represented among these genes, as were proteins with predicted signal peptide. Possibly reflecting the presence of regulatory sequences, the distribution of intergenic SNPs differed according to the function of the downstream open reading frame. A 3-way comparison of the newly sequenced anthroponotic C. parvum, the reference zoonotic C. parvum and the human parasite Cryptosporidium hominis identified genetic loci where the anthroponotic C. parvum sequence is more similar to C. hominis than to the zoonotic C. parvum reference. Because C. hominis and anthroponotic C. parvum share a similar host range, this unexpected observation suggests that proteins encoded by these genes may influence the host range.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.