ArticleNeurobiology of learning and memory2012
Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning.
Article in Neurobiology of learning and memory, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
60 citing papers in PubMed, 80 citations in OpenAlex.
- Memory under siege: the cognitive costs of smoking and vaping.Brain, behavior, & immunity - health · 2025Review
- Adolescent nicotine exposure affects later-life nicotine reward and withdrawal in mice.Pharmacology, biochemistry, and behavior · 2025Article
- Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats.Biomedicines · 2025Article
- Sex differences in contextual fear conditioning and extinction after acute and chronic nicotine treatment.Biology of sex differences · 2024Article
- The Transition from Childhood to Adolescence: Between Health and Vulnerability.Children (Basel, Switzerland) · 2024Review
- Article
- Consequences of adolescent drug use.Translational psychiatry · 2023Review
- Age-specific impacts of nicotine and withdrawal on hippocampal neuregulin signalling.The European journal of neuroscience · 2022Article
- Alcohol and Vaporized Nicotine Co-exposure During Adolescence Contribute Differentially to Sex-Specific Behavioral Effects in Adulthood.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
- The impact of adolescent stress on nicotine use and affective disorders in rodent models.The European journal of neuroscience · 2022Review
- Unique effects of nicotine across the lifespan.Pharmacology, biochemistry, and behavior · 2022Review
- Nicotine and opioid co-dependence: Findings from bench research to clinical trials.Neuroscience and biobehavioral reviews · 2022Review
- Chronic nicotine impairs sparse motor learning via striatal fast-spiking parvalbumin interneurons.Addiction biology · 2021Article
- Systems genetic analysis of nicotine withdrawal deficits in hippocampus-dependent learning.Genes, brain, and behavior · 2021Article
- Effects of Mephedrone and Amphetamine Exposure during Adolescence on Spatial Memory in Adulthood: Behavioral and Neurochemical Analysis.International journal of molecular sciences · 2021Article
- Unique, long-term effects of nicotine on adolescent brain.Pharmacology, biochemistry, and behavior · 2020Review
- Adolescent Cannabinoid and Nicotine Exposure Differentially Alters Adult Nicotine Self-Administration in Males and Females.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- The effects of adolescent alcohol exposure on learning and related neurobiology in humans and rodents.Neurobiology of learning and memory · 2020Review
- Stress and nicotine during adolescence disrupts adult hippocampal-dependent learning and alters stress reactivity.Addiction biology · 2020Article
- Differential expression of nicotine withdrawal as a function of developmental age in the rat.Pharmacology, biochemistry, and behavior · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Pre-adolescence and adolescence are developmental periods associated with increased vulnerability for tobacco addiction, and exposure to tobacco during these periods may lead to long-lasting changes in behavioral and neuronal plasticity. The present study examined the short- and long-term effects of nicotine and nicotine withdrawal on fear conditioning in pre-adolescent, adolescent, and adult mice, and potential underlying substrates that may mediate the developmental effects of nicotine, such as changes in nicotinic acetylcholine receptor (nAChR) binding, CREB expression, and nicotine metabolism. Age-related differences existed in sensitivity to the effects of acute nicotine, chronic nicotine and nicotine withdrawal on contextual fear conditioning (no changes in cued fear conditioning were seen); younger mice were more sensitive to the acute effects and less sensitive to the effects of nicotine withdrawal 24 h post treatment cessation. Developmental differences in nAChR binding were associated with the effects of nicotine withdrawal on contextual learning. Developmental differences in nicotine metabolism and CREB expression were also observed, but were not related to the effects of nicotine withdrawal on contextual learning 24 h post treatment. Chronic nicotine exposure during pre-adolescence or adolescence, however, produced long-lasting impairments in contextual learning that were observed during adulthood, whereas adult chronic nicotine exposure did not. These developmental effects could be related to changes in CREB. Overall, there is a developmental shift in the effects of nicotine on hippocampus-dependent learning and developmental exposure to nicotine results in adult cognitive deficits; these changes in cognition may play an important role in the development and maintenance of nicotine addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.