ArticleNitric oxide : biology and chemistry2012
Nitric oxide-dependent killing of aerobic, anaerobic and persistent Burkholderia pseudomallei.
Article in Nitric oxide : biology and chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Trial
- A nitric oxide-sensing two-component system regulates a range of infection-related phenotypes inmSphere · 2025Article
- NosP Detection of Heme ModulatesBiochemistry · 2023Article
- Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors.Microorganisms · 2023Review
- Antibacterial gas therapy: Strategies, advances, and prospects.Bioactive materials · 2023Review
- Nitric Oxide Inhibition of Rickettsia rickettsii.Infection and immunity · 2021Article
- Nitric oxide disrupts bacterial cytokinesis by poisoning purine metabolism.Science advances · 2020Article
- Reactive nitrogen species in host-bacterial interactions.Current opinion in immunology · 2019Review
- Differential effects of Th17 cytokines during the response of neutrophils toCentral-European journal of immunology · 2019Article
- Zinc-dependent substrate-level phosphorylation powers Salmonella growth under nitrosative stress of the innate host response.PLoS pathogens · 2018Article
- Burkholderia pseudomallei modulates host iron homeostasis to facilitate iron availability and intracellular survival.PLoS neglected tropical diseases · 2018Article
- Relative susceptibility of airway organisms to antimicrobial effects of nitric oxide.International forum of allergy & rhinology · 2017Article
- Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection.Scientific reports · 2016Article
- Delineating the importance of serum opsonins and the bacterial capsule in affecting the uptake and killing of Burkholderia pseudomallei by murine neutrophils and macrophages.PLoS neglected tropical diseases · 2014Article
- Nitric oxide from IFNγ-primed macrophages modulates the antimicrobial activity of β-lactams against the intracellular pathogens Burkholderia pseudomallei and Nontyphoidal Salmonella.PLoS neglected tropical diseases · 2014Article
- Deciphering nitric oxide stress in bacteria with quantitative modeling.Current opinion in microbiology · 2014Article
- Antibacterial responses of retinal Müller glia: production of antimicrobial peptides, oxidative burst and phagocytosis.Journal of neuroinflammation · 2014Article
- Fe(II) oxidation is an innate capability of nitrate-reducing bacteria that involves abiotic and biotic reactions.Journal of bacteriology · 2013Article
- Post-exposure therapeutic efficacy of COX-2 inhibition against Burkholderia pseudomallei.PLoS neglected tropical diseases · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Burkholderia pseudomallei infections are fastidious to treat with conventional antibiotic therapy, often involving a combination of drugs and long-term regimes. Bacterial genetic determinants contribute to the resistance of B. pseudomallei to many classes of antibiotics. In addition, anaerobiosis and hypoxia in abscesses typical of melioidosis select for persistent populations of B. pseudomallei refractory to a broad spectrum of antibacterials. We tested the susceptibility of B. pseudomallei to the drugs hydroxyurea, spermine NONOate and DETA NONOate that release nitric oxide (NO). Our investigations indicate that B. pseudomallei are killed by NO in a concentration and time-dependent fashion. The cytoxicity of this diatomic radical against B. pseudomallei depends on both the culture medium and growth phase of the bacteria. Rapidly growing, but not stationary phase, B. pseudomallei are readily killed upon exposure to the NO donor spermine NONOate. NO also has excellent antimicrobial activity against anaerobic B. pseudomallei. In addition, persistent bacteria highly resistant to most conventional antibiotics are remarkably susceptible to NO. Sublethal concentrations of NO inhibited the enzymatic activity of [4Fe-4S]-cofactored aconitase of aerobic and anaerobic B. pseudomallei. The strong anti-B. pseudomallei activity of NO described herein merits further studies on the application of NO-based antibiotics for the treatment of melioidosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.