Evidence map›Paper›PMID 22521335›Full record

ReviewProgress in neuro-psychopharmacology & biological psychiatry2012

New insights on endocannabinoid transmission in psychomotor disorders.

Andrea Giuffrida, Alexandre Seillier

Abstract readReview
In one paragraph

Review in Progress in neuro-psychopharmacology & biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Heteromers Formed by GPR55 and Either Cannabinoid CBInternational journal of molecular sciences · 2024
    Article
  3. Article
  4. Review
  5. Article
  6. Peripheral endocannabinoid system dysregulation in first-episode psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013
    Article
  7. Review
  8. Hub and switches: endocannabinoid signalling in midbrain dopamine neurons.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrea GiuffridaDepartment of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA. giuffrida@uthscsa.edu
Alexandre Seillier

Funding

Role of Endocannabinoids in Levodopa-Induced DyskinesiasR01NS050401 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GIUFFRIDA, ANDREA · 2005 to 2012
$2.3M
Endocannabinoid transmission in schizophreniaR01MH091130 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GIUFFRIDA, ANDREA · 2011 to 2015
$1.9M
NIMH NIH HHS MH9113001-A1NIMH NIH HHS R01 MH091130NINDS NIH HHS NS050401-07NINDS NIH HHS R01 NS050401
6 · The paper itself

Abstract

The endocannabinoids are lipid signaling molecules that bind to cannabinoid CB(1) and CB(2) receptors and other metabotropic and ionotropic receptors. Anandamide and 2-arachidonoyl glycerol, the two best-characterized examples, are released on demand in a stimulus-dependent manner by cleavage of membrane phospholipid precursors. Together with their receptors and metabolic enzymes, the endocannabinoids play a key role in modulating neurotransmission and synaptic plasticity in the basal ganglia and other brain areas involved in the control of motor functions and motivational aspects of behavior. This mini-review provides an update on the contribution of the endocannabinoid system to the regulation of psychomotor behaviors and its possible involvement in the pathophysiology of Parkinson's disease and schizophrenia.

Indexed as

Basal GangliaEndocannabinoidsHumansPsychomotor DisordersReceptors, CannabinoidSignal TransductionSynaptic TransmissionTRPC Cation ChannelsEndocannabinoidsReceptors, CannabinoidTRPC Cation Channels

Identifiers

PMID22521335
PMCPMC3389227

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.