ArticleBiological psychiatry2012
Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.
Article in Biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Genetic risk for schizophrenia modulates WIN 55,212-2 reward: Evidence from a heterozygous transmembrane domain neuregulin 1 mutant mouse model.Psychopharmacology · 2026Article
- Pharmacogenetic association study of cannabis use in chronic pain.Journal of cannabis research · 2026Article
- Neurotrophic Factors in Cannabis-induced Psychosis: An Update.Current topics in medicinal chemistry · 2024Review
- Impaired extinction of operant cocaine in a genetic mouse model of schizophrenia risk.Psychopharmacology · 2023Article
- Cannabinoids and Multiple Sclerosis: A Critical Analysis of Therapeutic Potentials and Safety Concerns.Pharmaceutics · 2023Review
- The genetic aetiology of cannabis use: from twin models to genome-wide association studies and beyond.Translational psychiatry · 2022Review
- The effects of preventative cannabidiol in a maleFrontiers in cellular neuroscience · 2022Article
- Association between platelet MAO activity and lifetime drug use in a longitudinal birth cohort study.Psychopharmacology · 2022Article
- Genetic Modulation of Initial Sensitivity to Δ9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice.Frontiers in genetics · 2021Article
- Sex and Strain Variation in Initial Sensitivity and Rapid Tolerance to Δ9-Tetrahydrocannabinol.Cannabis and cannabinoid research · 2020Article
- On the Modulatory Roles of Neuregulins/ErbB Signaling on Synaptic Plasticity.International journal of molecular sciences · 2019Review
- A review of bioanalytical techniques for evaluation of cannabis (Marijuana, weed, Hashish) in human hair.BMC chemistry · 2019Review
- Statistical Methods and Software for Substance Use and Dependence Genetic Research.Current genomics · 2019Review
- Pharmacogenetics of Cannabinoids.European journal of drug metabolism and pharmacokinetics · 2018Review
- The Endocannabinoid System across Postnatal Development in Transmembrane DomainFrontiers in psychiatry · 2018Article
- mGluR1-Dependent Long Term Depression in Rodent Midbrain Dopamine Neurons Is Regulated by Neuregulin 1/ErbB Signaling.Frontiers in molecular neuroscience · 2018Article
- Fathers' Alcohol and Cannabis Use Disorder and Early Onset of Drug Use by Their Children.Journal of studies on alcohol and drugs · 2017Article
- Seeing through the smoke: Human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks.Neuroscience and biobehavioral reviews · 2017Review
- The genetic basis of the comorbidity between cannabis use and major depression.Addiction (Abingdon, England) · 2017Article
- Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.JAMA psychiatry · 2016Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundA genetic contribution to cannabis dependence (CaD) has been established but susceptibility genes for CaD remain largely unknown.
methodsWe employed a multistage design to identify genetic variants underlying CaD. We first performed a genome-wide linkage scan for CaD in 384 African American (AA) and 354 European American families ascertained for genetic studies of cocaine and opioid dependence. We then conducted association analysis under the linkage peak, first using data from a genome-wide association study from the Study of Addiction: Genetics and Environment, followed by replication studies of prioritized single nucleotide polymorphisms (SNPs) in independent samples.
resultsWe identified the strongest linkage evidence with CaD (logarithm of odds = 2.9) on chromosome 8p21.1 in AAs. In the association analysis of the Study of Addiction: Genetics and Environment sample under the linkage peak, we identified one SNP (rs17664708) associated with CaD in both AAs (odds ratio [OR] = 2.93, p = .0022) and European Americans (OR = 1.38, p = .02). This SNP, located at NRG1, a susceptibility gene for schizophrenia, was prioritized for further study. We replicated the association of rs17664708 with CaD in an independent AAs sample (OR = 2.81, p = .0068). The joint analysis of the two AA samples demonstrated highly significant association between rs17664708 and CaD with adjustment for either global (p = .00044) or local ancestry (p = .00075).
conclusionsOur study shows that NRG1 is probably a susceptibility gene for CaD, based on convergent evidence of linkage and replicated associations in two independent AA samples.
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