ArticleBiological psychiatry2012
Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms.
Article in Biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Pathways to smoking behaviours: biological insights from the Tobacco and Genetics Consortium meta-analysis.Molecular psychiatry · 2017Pooled it
- Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.JAMA psychiatry · 2015Pooled it
- Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.Human molecular genetics · 2014Pooled it
- Additive genetic contribution to symptom dimensions in major depressive disorder.Journal of abnormal psychology · 2016Trial
- The Intergenerational Transfer of Mental Disorders: A Population-Based Multigenerational Linkage Study: Le transfert intergénérationnel des troubles mentaux : une étude sur les liens multigénérationnels basée sur la population.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2024Article
- SumVg: Total Heritability Explained by All Variants in Genome-Wide Association Studies Based on Summary Statistics with Standard Error Estimates.International journal of molecular sciences · 2024Article
- The Effects of Variation in the GABANeuropsychiatric disease and treatment · 2024Article
- Pathways link environmental and genetic factors with structural brain networks and psychopathology in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Article
- Genetic stratification of depression by neuroticism: revisiting a diagnostic tradition.Psychological medicine · 2020Article
- The association of depression and anxiety with cardiac autonomic activity: The role of confounding effects of antidepressants.Depression and anxiety · 2019Article
- Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Sociogenomics in the 21Sociology compass · 2018Article
- Genetic risk of major depressive disorder: the moderating and mediating effects of neuroticism and psychological resilience on clinical and self-reported depression.Psychological medicine · 2018Article
- Family History as an Important Factor for Stratifying Participants in Genetic Studies of Major Depression.Balkan journal of medical genetics : BJMG · 2018Article
- Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression.The American journal of psychiatry · 2018Article
- Phenotypic and genetic analysis of cognitive performance in Major Depressive Disorder in the Generation Scotland: Scottish Family Health Study.Translational psychiatry · 2018Article
- Genome-wide gene-environment interaction in depression: A systematic evaluation of candidate genes: The childhood trauma working-group of PGC-MDD.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
- Sample Size for Successful Genome-Wide Association Study of Major Depressive Disorder.Frontiers in genetics · 2018Article
- Psychiatric polygenic risk associates with cortical morphology and functional organization in aging.Translational psychiatry · 2017Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Genome-wide association studies of psychiatric disorders have been criticized for their lack of explaining a considerable proportion of the heritability established in twin and family studies. Genome-wide association studies of major depressive disorder in particular have so far been unsuccessful in detecting genome-wide significant single nucleotide polymorphisms (SNPs). Using two recently proposed methods designed to estimate the heritability of a phenotype that is attributable to genome-wide SNPs, we show that SNPs on current platforms contain substantial information concerning the additive genetic variance of major depressive disorder. To assess the consistency of these two methods, we analyzed four other complex phenotypes from different domains. The pattern of results is consistent with estimates of heritability obtained in twin studies carried out in the same population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.