ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2012
Factors associated with duration of new antidepressant treatment: analysis of a large primary care database.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Assessment of depression and anxiety after exposure to psychological trauma among females in Jordan: A cross-sectional study.Medicine · 2026Article
- Patterns and Duration of Antidepressant Use in Australian Women: Findings From the Australian Longitudinal Study on Women's Health.Asia-Pacific journal of public health · 2025Article
- Drug exposure misclassification in pharmacoepidemiology: Sources and relative impact.Pharmacoepidemiology and drug safety · 2021Article
- Socioeconomic position and mental health care use before and after first redeemed antidepressant and time until subsequent contact to psychologist or psychiatrists: a nationwide Danish follow-up study.Social psychiatry and psychiatric epidemiology · 2021Article
- Effect of income level on adherence to antidepressant treatment in first onset depression outpatients.PloS one · 2020Article
- Factors associated with discontinuation of antidepressant treatment after a single prescription among patients aged 55 or over: evidence from English primary care.Social psychiatry and psychiatric epidemiology · 2019Article
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- Determinants of follow-up care associated with incident antidepressant use in older adults.BMC research notes · 2017Article
- ANTIDEPRESSANT ADHERENCE ACROSS DIVERSE POPULATIONS AND HEALTHCARE SETTINGS.Depression and anxiety · 2016Article
- Monitoring patients on chronic treatment with antidepressants between 2003 and 2011: analysis of factors associated with compliance.BMC public health · 2015Article
- Explaining the variation between practices in the duration of new antidepressant treatment: a database cohort study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015Article
- An Analysis of Relapse Rates and Predictors of Relapse in 2 Randomized, Placebo-Controlled Trials of Desvenlafaxine for Major Depressive Disorder.The primary care companion for CNS disorders · 2015Article
- Patient factors associated with SSRI dose for depression treatment in general practice: a primary care cross sectional study.BMC family practice · 2014Article
- What happens next?: a claims database study of second-line pharmacotherapy in patients with major depressive disorder (MDD) who initiate selective serotonin reuptake inhibitor (SSRI) treatment.Annals of general psychiatry · 2014Article
- Maintenance use of antidepressants in Dutch general practice: non-guideline concordant.PloS one · 2014Article
- Trend in SSRI-SNRI antidepressants prescription over a 6-year period and predictors of poor adherence.European journal of clinical pharmacology · 2013Article
- Particular difficulties faced by GPs with young adults who will attempt suicide: a cross-sectional study.BMC family practice · 2013Article
- Incidence and drug treatment of emotional distress after cancer diagnosis: a matched primary care case-control study.British journal of cancer · 2012Article
- An end to depression in primary care?The British journal of general practice : the journal of the Royal College of General Practitioners · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundIt is not known how much the duration of newly prescribed antidepressant treatment is influenced by patient characteristics or practice variation.
aimTo describe the relationship between patient characteristics and the duration of new antidepressant treatment by general practices. DESIGN AND
settingLarge primary care database cohort study of all patients with a newly initiated course of eligible antidepressant treatment during 1 year, from a database of 237 Scottish practices.
methodDetailed prescription data were used to estimate the duration of new antidepressant treatment for each patient. Cox proportional hazards regression was used to estimate the influence of patient characteristics on continuation of treatment and, by multilevel modelling, the variation between practices.
resultsA total of 28 027 (2.2%) patients commenced antidepressant treatment during the year; 75% continued beyond 30 days, 56% beyond 90 days, and 40% beyond 180 days. Treatment was less likely to be continued in patients from areas of high socioeconomic deprivation: hazard ratio 1.22 (95% confidence interval [CI] = 1.16 to 1.29); in patients under 35 years, 1.33 (95% CI = 1.28 to 1.37); and in those for whom the GP recorded no relevant diagnostic code, 1.16 (95% CI = 1.13 to 1.18). Models accounted for between 2.2% and 3.9% of the variation in treatment duration.
conclusionPatient demographic characteristics account for relatively little variation in the duration of new antidepressant treatment, though treatment was shorter in younger patients and those with greater socioeconomic deprivation. There is variation in treatment duration between practices and according to whether patients have a depression diagnosis coded in their records.
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