ArticleChemistry & biology2012
Designing chimeric LOV photoswitches.
Article in Chemistry & biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bringing Light to Transcription: The Optogenetics Repertoire.Frontiers in genetics · 2018Review
- A circularly permuted photoactive yellow protein as a scaffold for photoswitch design.Biochemistry · 2013Article
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
Abstract
The LOV domain from Avena sativa has a C-terminal (Jα) helix that dissociates and unfolds when the protein is exposed to blue light. Using computational protein design methods, Lungu et al., in this issue of Chemistry & Biology, created chimeric Jα sequences that show photo-controlled interactions with chosen targets.
Identifiers
22520749What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.