Trial reportThe British journal of general practice : the journal of the Royal College of General Practitioners2012
The Fremantle Primary Prevention Study: a multicentre randomised trial of absolute cardiovascular risk reduction.
Trial report in The British journal of general practice : the journal of the Royal College of General Practitioners, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 4 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- General health checks in adults for reducing morbidity and mortality from disease.The Cochrane database of systematic reviews · 2019Pooled it
- Pooled it
- Risk scoring for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2017Pooled it
- Effectiveness of general practice-based health checks: a systematic review and meta-analysis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2014Pooled it
- Trial
- Training practitioners to deliver opportunistic multiple behaviour change counselling in primary care: a cluster randomised trial.BMJ (Clinical research ed.) · 2013Trial
- NHS health checks through general practice: randomised trial of population cardiovascular risk reduction.BMC public health · 2012Trial
- Making predictions under interventions: a case study from the PREDICT-CVD cohort in New Zealand primary care.Frontiers in epidemiology · 2024Article
- Using clinical prediction models to personalise lifestyle interventions for cardiovascular disease prevention: A systematic literature review.Preventive medicine reports · 2022Review
- Cost-effectiveness evaluation of the 45-49 year old health check versus usual care in Australian general practice: A modelling study.PloS one · 2018Article
- The Fremantle Primary Prevention Study: a multicentre randomised trial of absolute cardiovascular risk reduction.The British journal of general practice : the journal of the Royal College of General Practitioners · 2012Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiovascular disease (CVD) is the leading cause of global mortality. Risk factor management in clinical practice often relies on relative risk modification rather than the more appropriate absolute risk assessment.
aimTo determine whether patients receiving more-frequently designated GP visits had increased benefit in terms of their absolute CVD risk assessment, as compared with patients in receipt of their usual GP care. DESIGN AND
settingProspective, open, pragmatic block randomised study in a 1:1 group allocation ratio in three Western Australian general practices.
methodA convenience sample (n = 1200) of patients aged 40-80 years were randomised to 3-monthly GP visits (five in total for the intensive) or usual GP care (two in total for the opportunistic), with 12 months' follow-up. The main outcome was absolute CVD risk scores based on the New Zealand Cardiovascular Risk Calculator. Others outcome measures were weight, height, waist circumference, blood pressure, and fasting blood lipids and glucose.
resultsThere were 600 patients per group at baseline. At 12 months' analysis there were 543 in the intensive group and 569 in the opportunistic group. Mean (standard deviation [SD]) absolute CVD risk reduced significantly between baseline and 12 months in the intensive group (6.28% [5.11] to 6.10% [4.94]) but not in the opportunistic group (6.27% [5.10] to 6.24% [5.38]). There was a significant reduction between baseline and 12 months in mean (SD) total cholesterol (5.28 mmol/l [0.94] to 5.08 mmol/l [0.96]); low-density lipoprotein cholesterol (3.08 mmol/l [0.87] to 2.95 mmol/l [0.89]); triglyceride (1.45 mmol/l [0.86] to 1.36 mmol/l [0.84]); and in mean (SD) waist circumference in men (98.74 cm [10.70] to 97.13 cm [10.20]) and females (90.64 cm [14.62] to 88.96 cm [14.00]) in the intensive group.
conclusionA targeted approach using absolute risk calculators can be used in primary care to modify global CVD risk assessment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.