ArticleGenes, brain, and behavior2012
A polymorphic indel containing the RS3 microsatellite in the 5' flanking region of the vasopressin V1a receptor gene is associated with chimpanzee (Pan troglodytes) personality.
Article in Genes, brain, and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 78 citations in OpenAlex.
- Effects of arginine vasopressin on human anxiety and associations with sex, dose, and V1a-receptor genotype.Psychopharmacology · 2024Trial
- A yeast recombination system recapitulates the length polymorphism of a microsatellite implicated in human social behavior.NAR molecular medicine · 2026Article
- Article
- Genetic determinants of individual variation in the superior temporal sulcus of chimpanzees (Pan troglodytes).Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Chimpanzee Extraversion scores vary with epigenetic modification of dopamine receptor gene D2 (Epigenetics · 2022Article
- The Role of Serotonergic Gene Methylation in Regulating Anxiety-Related Personality Traits in Chimpanzees.Biology · 2022Article
- The promiscuity of the oxytocin-vasopressin systems and their involvement in autism spectrum disorder.Handbook of clinical neurology · 2021Review
- AVPR1A variation is linked to gray matter covariation in the social brain network of chimpanzees.Genes, brain, and behavior · 2020Article
- Association of Polymorphism of Arginine-Vasopressin Receptor 1A (Frontiers in human neuroscience · 2019Article
- Personality links with lifespan in chimpanzees.eLife · 2018Article
- Weak effects of common genetic variation in oxytocin and vasopressin receptor genes on rhesus macaque social behavior.American journal of primatology · 2018Article
- Prairie Voles as a Model for Understanding the Genetic and Epigenetic Regulation of Attachment Behaviors.ACS chemical neuroscience · 2018Review
- Common marmoset (Callithrix jacchus) personality, subjective well-being, hair cortisol level and AVPR1a, OPRM1, and DAT genotypes.Scientific reports · 2018Article
- Stabilizing selection on microsatellite allele length at arginine vasopressin 1a receptor and oxytocin receptor loci.Proceedings. Biological sciences · 2017Article
- Personality in the chimpanzees of Gombe National Park.Scientific data · 2017Article
- A human model for primate personality.Proceedings. Biological sciences · 2017Review
- Chimpanzee Personality and the Arginine Vasopressin Receptor 1A Genotype.Behavior genetics · 2017Article
- Article
- Triarchic Psychopathy Dimensions in Chimpanzees (Frontiers in neuroscience · 2017Article
- Dose-Dependent and Lasting Influences of Intranasal Vasopressin on Face Processing in Men.Frontiers in endocrinology · 2017Article
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3 authors at 3 institutions in 1 country.
Funding
Abstract
Vasopressin is a neuropeptide that has been strongly implicated in the development and evolution of complex social relations and cognition in mammals. Recent studies in voles have shown that polymorphic variation in the promoter region of the arginine vasopressin V1a receptor gene (avpr1a) is associated with different dimensions of sociality. In humans, variation in a repetitive sequence element in the 5' flanking region of the AVPR1A, known as RS3, have also been associated with variation in AVPR1a gene expression, brain activity and social behavior. Here, we examined the association of polymorphic variation in this same 5' flanking region of the AVPR1A on subjective ratings of personality in a sample of 83 chimpanzees (Pan troglodytes). Initial analyses indicated that 34 females and 19 males were homozygous for the short allele, which lacks RS3 (DupB(-/-)), while 18 females and 12 males were heterozygous and thus had one copy of the long allele containing RS3 (DupB(+/-)), yielding overall allelic frequencies of 0.82 for the DupB(-) allele and 0.18 for the DupB(+) allele. DupB(+/+) chimpanzees were excluded from the analysis because of the limited number of individuals. Results indicated no significant sex difference in personality between chimpanzees homozygous for the deletion of the RS3-containing DupB region (DupB(-/-)); however, among chimpanzees carrying one allele with the DupB present (DupB(+/-)), males had significantly higher dominance and lower conscientiousness scores than females. These findings are the first evidence showing that the AVPR1A gene plays a role in different aspects of personality in male and female chimpanzees.
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