ReviewHead & neck oncology2012
Clear cell chondrosarcoma of the head and neck.
Review in Head & neck oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Survival outcomes in laryngeal chondrosarcoma: a systematic review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2022Pooled it
- Chondrosarcoma: A comprehensive review of tumor biology, clinical behavior, and therapeutic advances.Cancer treatment reviews · 2026Review
- Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.Head and neck pathology · 2022Review
- Primary Sarcomas of the Larynx: A Clinicopathologic Study of 27 Cases.Head and neck pathology · 2021Article
- Long-term outcomes of grade I/II skull base chondrosarcoma: an insight into the role of surgery and upfront radiotherapy.Journal of neuro-oncology · 2021Article
- Differential Diagnosis between Oral Metastasis of Renal Cell Carcinoma and Salivary Gland Cancer.Diagnostics (Basel, Switzerland) · 2021Review
- Functional optimisation in chondrosarcoma of the subglottis: a novel surgical approach.BMJ case reports · 2021Article
- Soft Tissue Special Issue: Chondroid Neoplasms of the Skull.Head and neck pathology · 2020Review
- Contribution of Raman Spectroscopy to Diagnosis and Grading of Chondrogenic Tumors.Scientific reports · 2020Article
- Differing characteristics of cartilaginous lesions of the larynx.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Article
- Clear cell chondrosarcoma of the larynx.BMJ case reports · 2018Article
- Clear cell chondrosarcoma with secondary aneurysmal bone cyst changes.Singapore medical journal · 2014Article
- Primary laryngeal clear cell chondrosarcoma: report of a case and literature review.Head and neck pathology · 2014Review
- A New Insight into the Classification of Clear Cell Lesions of the Oral Cavity Based on the Diagnostic Modalities Used - A Review.Journal of microscopy and ultrastructureReview
Corrections and comments
- Expression of concern
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clear cell chondrosarcoma is a rare variant of chondrosarcoma that mostly involves the end of long bones. However, nine cases have been reported in the head and neck: four in larynx, two in nasal septum, two in maxilla and one in the skull. These cases form the basis of this review. Head and neck cases accounts for less than 5% of Clear cell chondrosarcomas in the whole body and the larynx is the most common place. The histological findings of head and neck cases are consistent with general features of this entity in the whole body and nearly all tumors in this case series had a component of conventional chondrosarcoma. Clear cell chondrosarcoma is an intracompartmental tumor and retains "Grenz zone" just beneath the epithelium. Therefore, the overlying mucosa remained intact in all laryngeal cases. Nasal tumor caused ballooning of the septum and the maxillary lesion did not involve the oral mucosa. This tumor presents various radiographic features in the head and neck area. Chondroblastoma, chondroma, osteoblastoma, osteosarcoma and metastatic renal cell carcinoma are included in the histologic differential diagnoses. Differentiation from chondroblastic osteosarcoma is important in the maxilla. A wide resection is adequate in most cases. However, some laryngeal cases show tendency to recur. Clear cell chondrosarcoma is a slow growing tumor and this necessitates a long time follow-up of patients. Due to the extreme rarity in the head and neck, diagnosis of Clear cell chondrosarcoma in this area, must be confirmed by histochemical and immunohistochemical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.