ReviewJournal of chromatography. A2012
Sample displacement chromatography as a method for purification of proteins and peptides from complex mixtures.
Review in Journal of chromatography. A, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Development of Liquid Chromatography on Monolithic Supports-From First Concepts to Real Analytical and Preparative Techniques.International journal of molecular sciences · 2025Review
- Fundamental Aspects of SPPS and Green Chemical Peptide Synthesis.Journal of peptide science : an official publication of the European Peptide Society · 2025Article
- Control of Pore Sizes in Epoxy Monoliths and Applications as Sheet-Type Adhesives in Combination with Conventional Epoxy and Acrylic Adhesives.Molecules (Basel, Switzerland) · 2024Article
- Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis.The Journal of organic chemistry · 2024Review
- High-throughput fractionation of human plasma for fast enrichment of low- and high-abundance proteins.Blood transfusion = Trasfusione del sangue · 2012Article
- Downstream Processing Technologies/Capturing and Final Purification : Opportunities for Innovation, Change, and Improvement. A Review of Downstream Processing Developments in Protein Purification.Advances in biochemical engineering/biotechnologyReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Sample displacement chromatography (SDC) in reversed-phase and ion-exchange modes was introduced approximately twenty years ago. This method takes advantage of relative binding affinities of components in a sample mixture. During loading, there is a competition among different sample components for the sorption on the surface of the stationary phase. SDC was first used for the preparative purification of proteins. Later, it was demonstrated that this kind of chromatography can also be performed in ion-exchange, affinity and hydrophobic-interaction mode. It has also been shown that SDC can be performed on monoliths and membrane-based supports in both analytical and preparative scale. Recently, SDC in ion-exchange and hydrophobic interaction mode was also employed successfully for the removal of trace proteins from monoclonal antibody preparations and for the enrichment of low abundance proteins from human plasma. In this review, the principals of SDC are introduced, and the potential for separation of proteins and peptides in micro-analytical, analytical and preparative scale is discussed.
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Registered trials
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