ArticleCritical care (London, England)2012
Early neurovascular uncoupling in the brain during community acquired pneumonia.
Article in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Clinical neurophysiological assessment of sepsis-associated brain dysfunction: a systematic review.Critical care (London, England) · 2014Pooled it
- Estimated Cerebral Perfusion Pressure and Intracranial Pressure in Septic Patients.Neurocritical care · 2024Article
- Sepsis-Induced Changes in Spectral Segregation and Kinetics of Hippocampal Oscillatory States in Rats.eNeuro · 2023Article
- High Mobility Group Box 1 (HMGB1): Potential Target in Sepsis-Associated Encephalopathy.Cells · 2023Review
- A summary of the current diagnostic methods for, and exploration of the value of microRNAs as biomarkers in, sepsis-associated encephalopathy.Frontiers in neuroscience · 2023Review
- The Use of Electroencephalography in Patients with Sepsis: a Review of The Literature.Journal of translational internal medicine · 2021Review
- Cerebral autoregulation and neurovascular coupling are progressively impaired during septic shock: an experimental study.Intensive care medicine experimental · 2020Article
- Septic-Associated Encephalopathy: a Comprehensive Review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Evaluation of Brain Nuclear Medicine Imaging Tracers in a Murine Model of Sepsis-Associated Encephalopathy.Molecular imaging and biology · 2018Article
- Cerebral Blood Flow Autoregulation in Sepsis for the Intensivist: Why Its Monitoring May Be the Future of Individualized Care.Journal of intensive care medicine · 2018Review
- Neuroanatomy of sepsis-associated encephalopathy.Critical care (London, England) · 2017Review
- Biomarkers of Delirium in a Low-Risk Community-Acquired Pneumonia-Induced Sepsis.Molecular neurobiology · 2017Article
- Transcranial Doppler to assess sepsis-associated encephalopathy in critically ill patients.BMC anesthesiology · 2014Observational
- The anesthetic effects on vasopressor modulation of cerebral blood flow in an immature swine model.Anesthesia and analgesia · 2013Article
- Transcranial doppler assessment of cerebral perfusion in critically ill septic patients: a pilot study.Annals of intensive care · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSepsis leads to microcirculatory dysfunction and therefore a disturbed neurovascular coupling in the brain. To investigate if the dysfunction is also present in less severe inflammatory diseases we studied the neurovascular coupling in patients suffering from community acquired pneumonia.
methodsPatients were investigated in the acute phase of pneumonia and after recovery. The neurovascular coupling was investigated with a simultaneous electroencephalogram (EEG)-Doppler technique applying a visual stimulation paradigm. Resting EEG frequencies, visual evoked potentials as well as resting and stimulated hemodynamic responses were obtained. Disease severity was characterized by laboratory and cognitive parameters as well as related scoring systems. Data were compared to a control group.
resultsWhereas visually evoked potentials (VEP) remained stable a significant slowing and therefore uncoupling of the hemodynamic responses were found in the acute phase of pneumonia (Rate time: control group: 3.6 ± 2.5 vs. acute pneumonia: 1.6 ± 2.4 s; P < 0.0005). In the initial investigation, patients who deteriorated showed a decreased hemodynamic response as compared with those who recovered (gain: recovered: 15% ± 4% vs. deteriorated: 9% ± 3%, P < 0.05; control: 14% ± 5%). After recovery the coupling normalized.
conclusionsOur study underlines the role of an early microcirculatory dysfunction in inflammatory syndromes that become evident in pre-septic conditions with a gradual decline according to disease severity.
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