ReviewDrugs2012
Sickle cell disease in children.
Review in Drugs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Health-Related Quality of Life of Children and Adolescents with Sickle Cell Disease in the Middle East and North Africa Region: A systematic review.Sultan Qaboos University medical journal · 2020Pooled it
- Systematic literature review and assessment of patient-reported outcome instruments in sickle cell disease.Health and quality of life outcomes · 2018Pooled it
- Using the consolidated framework for implementation research to identify recruitment barriers and targeted strategies for a shared decision-making randomized clinical trial in pediatric sickle cell disease.Clinical trials (London, England) · 2023Trial
- Physical Activity and Physical Fitness in Children and Adolescents Diagnosed With Sickle Cell Disease: A Scoping Review.American journal of lifestyle medicine · 2026Review
- Multifocal osteomyelitis and abscess due to Bacteroides caccae in a child with sickle cell disease.BMC pediatrics · 2026Article
- Parent and adolescent perspectives on decision-making involvement: A qualitative comparison in sickle cell and diabetes clinics.Patient education and counseling · 2026Article
- Article
- Early-life clinical and hematological profiles: a comparative study of children with and without sickle cell disease in the first three years of life.Annals of hematology · 2025Article
- Assessment of Biventricular Systolic and Diastolic Function Using Conventional and Strain Echocardiography in Children with Sickle Cell Disease Surviving 1-year After Hematopoietic Stem Cell Transplant.Pediatric cardiology · 2025Article
- Article
- Associations Between Pain Scores and Opioid Doses With Emergency Department Disposition and Return Visit Rates in Children With Sickle Cell Disease.Pediatric blood & cancer · 2025Article
- Understanding the role of asthma in acute chest syndrome: a comparative analysis of patients with and without asthma.Annals of hematology · 2025Article
- Cognitive considerations for adults with sickle cell disease completing the brief pain inventory.Pain reports · 2025Article
- The impact of comorbidities on the prognosis of patients with septic arthritis.Frontiers in medicine · 2025Review
- The impact of social vulnerability on primary vaccine coverage in children with sickle cell disease.Frontiers in public health · 2025Article
- Evolving Landscape of Sickle Cell Anemia Management in Africa: A Critical Review.Tropical medicine and infectious disease · 2024Review
- Return visit rates after an emergency department discharge for children with sickle cell pain episodes.Pediatric blood & cancer · 2023Article
- Sickle Cell Disease Newborn Screening-An Audit of a Twin Island State Pilot Program.International journal of neonatal screening · 2023Article
- Article
- Clinical features at diagnosis of sickle cell disease prior to universal newborn screening in Alberta.Paediatrics & child health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Early identification of infants with sickle cell disease (SCD) by newborn screening, now universal in all 50 states in the US, has improved survival, mainly by preventing overwhelming sepsis with the early use of prophylactic penicillin. Routine transcranial Doppler screening with the institution of chronic transfusion decreases the risk of stroke from 10% to 1% in paediatric SCD patients. Hydroxyurea decreases the number and frequency of painful crises, acute chest syndromes and number of blood transfusions in children with SCD. Genetic research continues to be driven toward the prevention and ultimate cure of SCD before adulthood. This review focuses on clinical manifestations and therapeutic strategies for paediatric SCD as well as the evolving topic of gene-focused prevention and therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.