ArticleAnalytical chemistry2012
IsoQuant: a software tool for stable isotope labeling by amino acids in cell culture-based mass spectrometry quantitation.
Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Activity-based protein profiling of the human failing ischemic heart reveals alterations in hydrolase activities involving the endocannabinoid system.Pharmacological research · 2020Article
- Inferring Protein-Protein Interaction Networks From Mass Spectrometry-Based Proteomic Approaches: A Mini-Review.Computational and structural biotechnology journal · 2019Review
- Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition.Nature neuroscience · 2018Article
- Characterization of the adult Aedes aegypti early midgut peritrophic matrix proteome using LC-MS.PloS one · 2018Article
- Mass Spectrometry Analysis of Lysine Posttranslational Modifications of Tau Protein from Alzheimer's Disease Brain.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Classification-based quantitative analysis of stable isotope labeling by amino acids in cell culture (SILAC) data.Computer methods and programs in biomedicine · 2016Article
- Human DNA Ligase I Interacts with and Is Targeted for Degradation by the DCAF7 Specificity Factor of the Cul4-DDB1 Ubiquitin Ligase Complex.The Journal of biological chemistry · 2016Article
- Glycoproteomic Approach Identifies KRAS as a Positive Regulator of CREG1 in Non-small Cell Lung Cancer Cells.Theranostics · 2016Article
- Redefining the Breast Cancer Exosome Proteome by Tandem Mass Tag Quantitative Proteomics and Multivariate Cluster Analysis.Analytical chemistry · 2015Article
- Article
- An Internal Standard-Assisted Synthesis and Degradation Proteomic Approach Reveals the Potential Linkage between VPS4B Depletion and Activation of Fatty Acid β-Oxidation in Breast Cancer Cells.International journal of proteomics · 2013Article
- High-capacity peptide-centric platform to decode the proteomic response to brain injury.Electrophoresis · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Accurate protein identification and quantitation are critical when interpreting the biological relevance of large-scale shotgun proteomics data sets. Although significant technical advances in peptide and protein identification have been made, accurate quantitation of high-throughput data sets remains a key challenge in mass spectrometry data analysis and is a labor intensive process for many proteomics laboratories. Here, we report a new SILAC-based proteomics quantitation software tool, named IsoQuant, which is used to process high mass accuracy mass spectrometry data. IsoQuant offers a convenient quantitation framework to calculate peptide/protein relative abundance ratios. At the same time, it also includes a visualization platform that permits users to validate the quality of SILAC peptide and protein ratios. The program is written in the C# programming language under the Microsoft .NET framework version 4.0 and has been tested to be compatible with both 32-bit and 64-bit Windows 7. It is freely available to noncommercial users at http://www.proteomeumb.org/MZw.html .
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