Evidence map›Paper›PMID 22519410›Full record

ArticleAllergy2012

Undernotification of anaphylaxis deaths in Brazil due to difficult coding under the ICD-10.

L K Tanno, F Ganem, P Demoly, C M Toscano, A L Bierrenbach

Abstract read
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In one paragraph

Article in Allergy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Incidence of fatal food anaphylaxis in people with food allergy: a systematic review and meta-analysis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2013
    Pooled it
  2. Global Burden of Drug-Induced Anaphylaxis Associated With 33 Classes of Antibiotics (1968-2024): A Pharmacovigilance Analysis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025
    Article
  3. Anaphylaxis and pregnancy: Epidemiology, elicitors, and recurrences.The World Allergy Organization journal · 2025
    Article
  4. Who is at-risk for severe anaphylaxis in France?The World Allergy Organization journal · 2024
    Article
  5. Review
  6. Fatal food anaphylaxis in adults and children.Italian journal of pediatrics · 2024
    Review
  7. Global disparities in availability of epinephrine auto-injectors.The World Allergy Organization journal · 2023
    Article
  8. Article
  9. Food allergy in the World Health Organization's International Classification of Diseases (ICD)-11.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Review
  10. Article
  11. Anaphylaxis in Brazil between 2011 and 2019.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Critical view of anaphylaxis epidemiology: open questions and new perspectives.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

L K TannoEmergency Department, Hospital Sírio Libanês, São Paulo, Brazil. lucianatanno@terra.com.br
F Ganem
P Demoly
C M Toscano
A L Bierrenbach

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUndernotification is well recognized as a key challenge to the study of anaphylaxis mortality, but it is seldom mentioned that one of its reasons is the difficult coding of the condition under the tenth revision of the international classification of diseases (ICD-10), given that there are no anaphylaxis-specific ICD-10, which are considered valid for coding underlying causes-of-death, and that official mortality statistics consider exclusively the underlying and disregard the contributing causes-of-death data recorded on death certificates. Brazilian mortality data were used as a case study to call attention to the inadequacy of the ICD-10 for the measurement of anaphylaxis deaths.

methodsUnderlying and contributing causes-of-death data were used to estimate the rates of anaphylaxis deaths in the country over the years 2008-2010.

resultsOf 498 anaphylaxis deaths were found, of which 75% were classified as 'definite' and 25% as 'possible anaphylaxis deaths'. The average national rate for these years was 0.87 per million per year. None of these deaths would have been found had we exclusively considered information from the underlying cause-of-death field. CONCLUSION/RECOMMENDATIONS: The study of anaphylaxis mortality using secondary data requires the use of information derived from the underlying as well as from the contributing causes-of-death fields. Coding definitions should be standardized with a view of enabling trend analyses and international comparisons. The ICD-11 revision is a unique opportunity to improve the coding system so as to facilitate epidemiological studies of anaphylaxis mortality. Educational interventions targeted at improving the quality of death certificate completion are urgently needed.

Indexed as

Cause of DeathAdolescentAdultAnaphylaxisBrazilChildChild, PreschoolClinical CodingFemaleHumansInfantInfant, NewbornInternational Classification of DiseasesMaleMiddle AgedYoung Adult

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.