ArticleThe Journal of biological chemistry2012
Period of irreversible therapeutic intervention during sepsis correlates with phase of innate immune dysfunction.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Early single session of hyperbaric oxygen therapy mitigates renal apoptosis in lipopolysaccharides-induced endotoxemia in rats.Kidney research and clinical practice · 2025Article
- iRhom2 deficiency reduces sepsis-induced mortality associated with the attenuation of lung macrophages in mice.Histochemistry and cell biology · 2024Article
- Enhancing SAPS-3 Predictive Accuracy with Initial, Peak, and Last Lactate Measurements in Septic Shock.Journal of clinical medicine · 2024Article
- Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival.iScience · 2023Article
- Mitochondrial protective effects caused by the administration of mefenamic acid in sepsis.Journal of neuroinflammation · 2022Article
- Persistence of Lipoproteins and Cholesterol Alterations after Sepsis: Implication for Atherosclerosis Progression.International journal of molecular sciences · 2021Review
- Regulation of theInfection and immunity · 2021Article
- Stress proteins as predictors of COVID-19 outcomes.Cell stress & chaperones · 2021Article
- COVID-19, acute respiratory distress syndrome (ARDS), and hyperbaric oxygen therapy (HBOT): what is the link?Cell stress & chaperones · 2020Article
- Kinin B1 receptor: a potential therapeutic target in sepsis-induced vascular hyperpermeability.Journal of translational medicine · 2020Article
- Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R-mediated STAT3 activation.JCI insight · 2020Article
- The Contribution of the Omentum to the Outcome From Sepsis: An Experimental Animal Study.Shock (Augusta, Ga.) · 2019Article
- Early hyperbaric oxygen therapy improves survival in a model of severe sepsis.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Macrophage reprogramming by negatively charged membrane phospholipids controls infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- The GTPase Rab1 Is Required for NLRP3 Inflammasome Activation and Inflammatory Lung Injury.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Why Antibiotic Treatment Is Not Enough for Sepsis Resolution: an Evaluation in an Experimental Animal Model.Infection and immunity · 2017Article
- Morphology-Independent Virulence of Candida Species during Polymicrobial Intra-abdominal Infections with Staphylococcus aureus.Infection and immunity · 2016Article
- Elevated expression of IL-23/IL-17 pathway-related mediators correlates with exacerbation of pulmonary inflammation during polymicrobial sepsis.Shock (Augusta, Ga.) · 2014Article
- What can we learn from elegant clinical studies?*.Critical care medicine · 2014Article
- Post challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood.Innate immunity · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Sepsis is a major health problem in the United States with high incidence and elevated patient care cost. Using an animal model of sepsis, cecum ligation, and puncture, we observed that mice became rapidly hypothermic reaching a threshold temperature of 28 °C within 5-10 h after initiation of the insult, resulting in a reliable predictor of mortality, which occurred within 30-72 h of the initial procedure. We also observed that the inflammatory gene expression in lung and liver developed early within 1-2 h of the insult, reaching maximum levels at 6 h, followed by a decline, approaching basal conditions within 20 h. This decrease in inflammatory gene expression at 20 h after cecal ligation and puncture was not due to resolution of the insult but rather was an immune dysfunction stage that was demonstrated by the inability of the animal to respond to a secondary external inflammatory stimulus. Removal of the injury source, ligated cecum, within 6 h of the initial insult resulted in increased survival, but not after 20 h of cecal ligation and puncture. We concluded that the therapeutic window for resolving sepsis is early after the initial insult and coincides with a stage of hyperinflammation that is followed by a condition of innate immune dysfunction in which reversion of the outcome is no longer possible.
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Registered trials
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