Evidence map›Paper›PMID 22518835›Full record

Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2012

Resistance exercise load does not determine training-mediated hypertrophic gains in young men.

Cameron J Mitchell, Tyler A Churchward-Venne, Daniel W D West, Nicholas A Burd, Leigh Breen, Steven K Baker, Stuart M Phillips

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 249 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 15 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04547972 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effects of Higher- And Lower-Load Resistance Exercise Training on Leg and Arm Skeletal Muscle Mass in Healthy Young Adult Females

TypeinterventionalSponsorUniversity of British ColumbiaRan2021 to 2021Enrolled16ConditionsSkeletal Muscle HypertrophyArmsHigher-load resistance training, Lower-load resistance training
NCT05573321 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Blood Flow Restriction Exercise on Acute Systemic Irisin, Myostatin and Decorin Levels

TypeinterventionalSponsorEge UniversityRan2023 to 2023Enrolled22ConditionsMuscle HypotrophyArmsBFR-RE, HL-RE
NCT06413199 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Adaptive Response of Brain Towards Resistance Training in Healthy Individuals

TypeinterventionalSponsorPakistan Society for Rehabilitation of Differently Abled HospitalRan2023 to 2024Enrolled100ConditionsResistance TrainingArmsHyper Training, 1 Repetition maximum training group
3 · Its place in the literature

Who cites it

249 citing papers in PubMed, 15 syntheses or guidelines pooled it, 625 citations in OpenAlex.

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  11. Maximizing Muscle Hypertrophy: A Systematic Review of Advanced Resistance Training Techniques and Methods.International journal of environmental research and public health · 2019
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189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cameron J MitchellExercise Metabolism Research Group, Department of Kinesiology, McMaster Univ., 1280 Main St., West, Hamilton, Ontario, L8S4L8, Canada.
Tyler A Churchward-Venne
Daniel W D West
Nicholas A Burd
Leigh Breen
Steven K Baker
Stuart M Phillips
McMaster University · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

We have reported that the acute postexercise increases in muscle protein synthesis rates, with differing nutritional support, are predictive of longer-term training-induced muscle hypertrophy. Here, we aimed to test whether the same was true with acute exercise-mediated changes in muscle protein synthesis. Eighteen men (21 ± 1 yr, 22.6 ± 2.1 kg/m(2); means ± SE) had their legs randomly assigned to two of three training conditions that differed in contraction intensity [% of maximal strength (1 repetition maximum)] or contraction volume (1 or 3 sets of repetitions): 30%-3, 80%-1, and 80%-3. Subjects trained each leg with their assigned regime for a period of 10 wk, 3 times/wk. We made pre- and posttraining measures of strength, muscle volume by magnetic resonance (MR) scans, as well as pre- and posttraining biopsies of the vastus lateralis, and a single postexercise (1 h) biopsy following the first bout of exercise, to measure signaling proteins. Training-induced increases in MR-measured muscle volume were significant (P < 0.01), with no difference between groups: 30%-3 = 6.8 ± 1.8%, 80%-1 = 3.2 ± 0.8%, and 80%-3= 7.2 ± 1.9%, P = 0.18. Isotonic maximal strength gains were not different between 80%-1 and 80%-3, but were greater than 30%-3 (P = 0.04), whereas training-induced isometric strength gains were significant but not different between conditions (P = 0.92). Biopsies taken 1 h following the initial resistance exercise bout showed increased phosphorylation (P < 0.05) of p70S6K only in the 80%-1 and 80%-3 conditions. There was no correlation between phosphorylation of any signaling protein and hypertrophy. In accordance with our previous acute measurements of muscle protein synthetic rates a lower load lifted to failure resulted in similar hypertrophy as a heavy load lifted to failure.

Indexed as

BiopsyHumansHypertrophyMaleMuscle ContractionMuscle ProteinsMuscle, SkeletalMuscle StrengthPhosphorylationResistance TrainingRibosomal Protein S6 Kinases, 70-kDaSignal TransductionWeight LiftingYoung AdultMuscle ProteinsRibosomal Protein S6 Kinases, 70-kDa

Identifiers

PMID22518835
PMCPMC3404827
OpenAlexW2137046611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.