Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Toward a positive aging phenotype for older women: observations from the women's health initiative.
Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Physiological phenotypes have optimal values relevant to healthy aging: sweet spots deduced from the Canadian Longitudinal Study on Aging.GeroScience · 2024Article
- Physical and Behavioral Factors Associated With Improvement in Physical Health and Function Among US Women During Midlife.JAMA network open · 2023Article
- What Is Successful Aging in Lesbian and Bisexual Women? Application of the Aging-Well Model.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Midlife Factors Related to Psychological Well-Being at an Older Age: Study of Women's Health Across the Nation.Journal of women's health (2002) · 2021Article
- Potential Benefits of Physical Activity in MCI and Dementia.Behavioural neurology · 2020Review
- Domains and Measurements of Healthy Aging in Epidemiological Studies: A Review.The Gerontologist · 2019Review
- Genetic cartography of longevity in humans and mice: Current landscape and horizons.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
- Age-Related Biomarkers in LLFS Families With Exceptional Cognitive Abilities.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Genetic Analysis of Mitochondrial Ribosomal Proteins and Cognitive Aging in Postmenopausal Women.Frontiers in genetics · 2017Article
- HIV and Aging Research in Women: An Overview.Current HIV/AIDS reports · 2016Review
- Is self-reported physical functioning associated with incident cardiometabolic abnormalities or the metabolic syndrome?Diabetes/metabolism research and reviews · 2016Article
- Identification of Risk Factors for Mortality and Poor-Quality-of-Life Survival in Frail Older Women Participating in the Women's Health Initiative Observational Study.Journal of the American Geriatrics Society · 2016Observational
- Correlates of Successful Aging in Racial and Ethnic Minority Women Age 80 Years and Older: Findings from the Women's Health Initiative.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Aging Well: Observations From the Women's Health Initiative Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Predictors of Optimal Cognitive Aging in 80+ Women: The Women's Health Initiative Memory Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Risk of Mortality According to Body Mass Index and Body Composition Among Postmenopausal Women.American journal of epidemiology · 2015Article
- Global quality of life modifies terminal change in physical functioning among older adult women.Age and ageing · 2015Article
- Lower extremity function trajectories in the African American Health Cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
backgroundTo develop a positive aging phenotype, we undertook analyses to describe multiple dimensions of positive aging and their relationships to one another in women 65 years of age and older and evaluate the performance of individual indicators and composite factors of this phenotype as predictors of time to death, years of healthy living, and years of independent living.
methodsData from Women's Health Initiative clinical trial and observational study participants ages 65 years and older at baseline, including follow-up observations up to 8 years later, were analyzed using descriptive statistics and principal components analysis to identify the factor structure of a positive aging phenotype. The factors were used to predict time to death, years of healthy living (without hospitalization or diagnosis of a serious health condition), and years of independent living (without nursing home admission or use of special services).
resultsWe identified a multidimensional phenotype of positive aging that included two factors: Physical-Social Functioning and Emotional Functioning. Both factors were predictive of each of the outcomes, but Physical-Social Functioning was the strongest predictor. Each standard deviation of increase in Physical-Social Functioning was accompanied by a 23.7% reduction in mortality risk, a 19.4% reduction in risk of major health conditions or hospitalizations, and a 26.3% reduction in risk of dependent living.
conclusionsPhysical-Social Functioning and Emotional Functioning constitute important components of a positive aging phenotype. Physical-Social Functioning was the strongest predictor of outcomes related to positive aging, including years of healthy living, years of independent living, and time to mortality.
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