Trial reportPain research & management
Pain catastrophizing predicts poor response to topical analgesics in patients with neuropathic pain.
Trial report in Pain research & management. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 70 citations in OpenAlex.
- Response to High-Dose Topical Capsaicin in Neuropathic Pain: Absence of Deep Pain as a Predictor of Analgesic Effect.European journal of pain (London, England) · 2026Article
- Perspectives on Pain: A Narrative Review of Pain Beliefs, Coping, and Clinical Implications.Journal of pain research · 2026Review
- Context is Complex: Challenges and opportunities addressing contextual factors in manual therapy mechanisms research.International journal of osteopathic medicine : IJOM · 2025Article
- The phenotype of recovery XII: A reinforcer pathology perspective on associations between delay discounting and pain catastrophizing in substance use disorder recovery.Journal of substance use and addiction treatment · 2025Article
- Fibromyalgia pain management effectiveness from the patient perspective: a qualitative evidence synthesis.Disability and rehabilitation · 2024Review
- Interdisciplinary pain program participants with high catastrophizing scores improve function utilizing enriched therapeutic encounters and integrative health techniques: a retrospective study.Frontiers in psychology · 2024Article
- Article
- Whole-Body Photobiomodulation Therapy for Fibromyalgia: A Feasibility Trial.Behavioral sciences (Basel, Switzerland) · 2023Article
- The Relationship between Pain Catastrophizing and Cognitive Function in Chronic Musculoskeletal Pain: A Scoping Review.Pain research & management · 2023Article
- Effects of High-Definition Transcranial Direct Current Stimulation Over the Primary Motor Cortex on Cold Pain Sensitivity Among Healthy Adults.Frontiers in molecular neuroscience · 2022Article
- Frontal alpha asymmetry: A potential biomarker of approach-withdrawal motivation towards pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Age differences in cognitive-affective processes in adults with chronic pain.European journal of pain (London, England) · 2021Article
- Ethnic Differences in Experimental Pain Responses Following a Paired Verbal Suggestion With Saline Infusion: A Quasiexperimental Study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2021Article
- Understanding the Psychological, Physiological, and Genetic Factors Affecting Precision Pain Medicine: A Narrative Review.Journal of pain research · 2021Review
- Opioid Pain Medication Prescription for Chronic Pain in Primary Care Centers: The Roles of Pain Acceptance, Pain Intensity, Depressive Symptoms, Pain Catastrophizing, Sex, and Age.International journal of environmental research and public health · 2020Article
- Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice.Scientific reports · 2019Article
- A systematic review of structural and functional MRI studies on pain catastrophizing.Journal of pain research · 2019Article
- Evaluating psychosocial contributions to chronic pain outcomes.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Linguistic Indicators of Pain Catastrophizing in Patients With Chronic Musculoskeletal Pain.The journal of pain · 2017Article
- The Key Role of Pain Catastrophizing in the Disability of Patients with Acute Back Pain.International journal of behavioral medicine · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrevious research suggests that high levels of pain catastrophizing might predict poorer response to pharmacological interventions for neuropathic pain.
objectiveThe present study sought to examine the clinical relevance of the relation between catastrophizing and analgesic response in individuals with neuropathic pain. Clinically meaningful reductions were defined in terms of the magnitude of reductions in pain through the course of treatment, and in terms of the number of patients whose end-of-treatment pain ratings were below 4⁄10.
methodsPatients (n=82) with neuropathic pain conditions completed a measure of pain catastrophizing at the beginning of a three-week trial examining the efficacy of topical analgesics for neuropathic pain.
resultsConsistent with previous research, high scores on the measure of pain catastrophizing prospectively predicted poorer response to treatment. Fewer catastrophizers than noncatastrophizers showed moderate (≥ 2 points) or substantial reductions in pain ratings through the course of treatment. Fewer catastrophizers than noncatastrophizers achieved end-of-treatment pain ratings below 4⁄10.
conclusionsThe results of the present study suggest that the development of brief interventions specifically targeting catastrophic thinking might be useful for enhancing the effects of pharmacological interventions for neuropathic pain. Furthermore, failure to account for the level of catastrophizing might contribute to null findings in clinical trials of analgesic medication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.