ArticleInternational journal of hypertension2012
Deficiency of ACE2 in Bone-Marrow-Derived Cells Increases Expression of TNF-α in Adipose Stromal Cells and Augments Glucose Intolerance in Obese C57BL/6 Mice.
Article in International journal of hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- SARS-CoV-2 and endothelial cell interaction in COVID-19: molecular perspectives.Vascular biology (Bristol, England) · 2021Review
- Retinal Microcirculation as a Correlate of a Systemic Capillary Impairment After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.Frontiers in medicine · 2021Article
- Diminazen Aceturate Protects Pulmonary Ischemia-Reperfusion Injury via Inhibition of ADAM17-Mediated Angiotensin-Converting Enzyme 2 Shedding.Frontiers in pharmacology · 2021Article
- Linking ACE2 and angiotensin II to pulmonary immunovascular dysregulation in SARS-CoV-2 infection.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020Article
- Bone biology and COVID-19 infection: Is ACE2 a potential influence factor?Medical hypotheses · 2020Article
- Endocrine Significance of SARS-CoV-2's Reliance on ACE2.Endocrinology · 2020Review
- Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications.Life sciences · 2020Review
- COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options.Cardiovascular research · 2020Article
- ACE2 and COVID-19: using antihypertensive medications and pharmacogenetic considerations.Pharmacogenomics · 2020Review
- Would Repurposing Minocycline Alleviate Neurologic Manifestations of COVID-19?Frontiers in neuroscience · 2020Article
- COVID-19: Underlying Adipokine Storm and Angiotensin 1-7 Umbrella.Frontiers in immunology · 2020Article
- Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 Pathology.International journal of hypertension · 2020Review
- ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity.Diabetes · 2016Article
- ACE2, angiotensin-(1–7), and Mas: the other side of the coin.Pflugers Archiv : European journal of physiology · 2013Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Deficiency of ACE2 in macrophages has been suggested to promote the development of an inflammatory M1 macrophage phenotype. We evaluated effects of ACE2 deficiency in bone-marrow-derived stem cells on adipose inflammation and glucose tolerance in C57BL/6 mice fed a high fat (HF) diet. ACE2 activity was increased in the stromal vascular fraction (SVF) isolated from visceral, but not subcutaneous adipose tissue of HF-fed mice. Deficiency of ACE2 in bone marrow cells significantly increased mRNA abundance of F4/80 and TNF-α in the SVF isolated from visceral adipose tissue of HF-fed chimeric mice, supporting increased presence of inflammatory macrophages in adipose tissue. Moreover, deficiency of ACE2 in bone marrow cells modestly augmented glucose intolerance in HF-fed chimeric mice and increased blood levels of glycosylated hemoglobin. In summary, ACE2 deficiency in bone marrow cells promotes inflammation in adipose tissue and augments obesity-induced glucose intolerance.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.