ArticleInternational journal of hypertension2012
Angiotensin converting enzyme 2, Angiotensin-(1-7), and receptor MAS axis in the kidney.
Article in International journal of hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Influence of glucagon-like peptide-1 receptor agonists on renal parameters: a meta-analysis of randomized controlled trials.BMC endocrine disorders · 2025Pooled it
- Low Ang-(1-7) and high des-Arg9 bradykinin serum levels are correlated with cardiovascular risk factors in patients with COVID-19.Open medicine (Warsaw, Poland) · 2023Article
- ACE2 negatively regulates the Warburg effect and suppresses hepatocellular carcinoma progression via reducing ROS-HIF1α activity.International journal of biological sciences · 2023Article
- View of the Renin-Angiotensin System in Acute Kidney Injury Induced by Renal Ischemia-Reperfusion Injury.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2022Review
- Catechins: Therapeutic Perspectives in COVID-19-Associated Acute Kidney Injury.Molecules (Basel, Switzerland) · 2021Review
- Effect of Mineralocorticoid Receptor Antagonism and ACE Inhibition on Angiotensin Profiles in Diabetic Kidney Disease: An Exploratory Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021Article
- Renal Manifestations of Covid-19: Physiology and Pathophysiology.Journal of clinical medicine · 2021Review
- Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases.Clinical science (London, England : 1979) · 2021Review
- Molecular Mechanisms Involved in Intrarenal Renin-Angiotensin and Alternative Pathways in Diabetic Nephropathy - A Review.The review of diabetic studies : RDS · 2021Review
- Angiotensin-Converting Enzyme 2 in the Pathogenesis of Renal Abnormalities Observed in COVID-19 Patients.Frontiers in physiology · 2021Review
- Angiotensin 1-7: A Novel Strategy in COVID-19 Treatment.Advanced pharmaceutical bulletin · 2020Article
- Why Children are Less Likely to Contract COVID-19 Infection than Adults?International journal of preventive medicine · 2020Article
- ARNi: A Novel Approach to Counteract Cardiovascular Diseases.International journal of molecular sciences · 2019Review
- Angiotensin-(1-7) inhibits sodium transport via Mas receptor by increasing nitric oxide production in thick ascending limb.Physiological reports · 2019Article
- Spironolactone rescues renal dysfunction in obstructive jaundice rats by upregulating ACE2 expression.Journal of cell communication and signaling · 2019Article
- Factors regulating the renal circulation in spontaneously hypertensive rats.Saudi journal of biological sciences · 2016Review
- Regulation of Dopamine Uptake by Vasoactive Peptides in the Kidney.Scientifica · 2016Article
- Is the renin-angiotensin system actually hypertensive?Pediatric nephrology (Berlin, Germany) · 2014Review
- Novel role of aminopeptidase-A in angiotensin-(1-7) metabolism post myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2014Article
- The preventive effects of diminazene aceturate in renal ischemia/reperfusion injury in male and female rats.Advances in preventive medicine · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the past few years the understanding of the renin-angiotensin system (RAS) has improved, helping to better define the role of this system in physiological conditions and in human diseases. Besides Angiotensin (Ang) II, the biological importance of other Ang fragments was progressively evidenced. In this regard, Angiotensin- (Ang-) (1-7) was recognized as a biologically active product of the RAS cascade with a specific receptor, the G-protein-coupled receptor Mas, and that is mainly formed by the action of the angiotensin-converting enzyme (ACE) homolog enzyme, ACE2, which converts Ang II into Ang-(1-7). Taking into account the biological effects of these two mediators, Ang II and Ang-(1-7), the RAS can be envisioned as a dual function system in which the vasoconstrictor/proliferative or vasodilator/antiproliferative actions are primarily driven by the balance between Ang II and Ang-(1-7), respectively. In this paper, we will discuss our current understanding of the ACE2/Ang-(1-7)/Mas axis of the RAS in renal physiology and in the pathogenesis of primary hypertension and chronic kidney disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.