ArticleInternational journal of pediatrics2012
Respiratory support in meconium aspiration syndrome: a practical guide.
Article in International journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
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Who cites it
13 citing papers in PubMed, 61 citations in OpenAlex.
- Effect of Nasal Continuous Positive Airway Pressure on Infants With Meconium Aspiration Syndrome: A Randomized Clinical Trial.JAMA pediatrics · 2018Trial
- Neonatal complications and referral practices at birth: insights from a population-based study in the Indian state of Bihar.BMJ open · 2025Article
- Article
- Meconium aspiration syndrome: from pathophysiology to treatment.Annals of medicine and surgery (2012) · 2024Review
- Meconium aspiration syndrome: a comprehensive review.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Safety use of high frequency oscillatory ventilation in transport of newborn infants affected by severe respiratory failure: preliminary data in central Tuscany.BMC pediatrics · 2022Article
- Determinants of meconium aspiration syndrome among neonates admitted to neonatal intensive care unit at Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital, South Ethiopia: Unmatched case-control study.SAGE open medicine · 2022Article
- Is meconium exposure associated with autism spectrum disorders in children?Clinical and experimental pediatrics · 2021Article
- The "Hub and Spoke" (HandS) ECMO for "Resuscitating" Neonates with Respiratory Life-Threatening Conditions.Children (Basel, Switzerland) · 2021Article
- Meconium aspiration pneumonia and otitis media in two goat kids.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2019Article
- Recombinant Human Superoxide Dismutase andMolecules (Basel, Switzerland) · 2019Article
- Efficiency of high-frequency oscillatory ventilation combined with pulmonary surfactant in the treatment of neonatal meconium aspiration syndrome.International journal of clinical and experimental medicine · 2015Article
- Meconium Influences Pulmonary Short-Chain Fatty Acid Concentration in Porcine Meconium Aspiration Model.Biomedicine hubArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meconium aspiration syndrome (MAS) is a complex respiratory disease of the term and near-term neonate. Inhalation of meconium causes airway obstruction, atelectasis, epithelial injury, surfactant inhibition, and pulmonary hypertension, the chief clinical manifestations of which are hypoxaemia and poor lung compliance. Supplemental oxygen is the mainstay of therapy for MAS, with around one-third of infants requiring intubation and mechanical ventilation. For those ventilated, high ventilator pressures, as well as a relatively long inspiratory time and slow ventilator rate, may be necessary to achieve adequate oxygenation. High-frequency ventilation may offer a benefit in infants with refractory hypoxaemia and/or gas trapping. Inhaled nitric oxide is effective in those with pulmonary hypertension, and other adjunctive therapies, including surfactant administration and lung lavage, should be considered in selected cases. With judicious use of available modes of ventilation and adjunctive therapies, infants with even the most severe MAS can usually be supported through the disease, with an acceptably low risk of short- and long-term morbidities.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.