ArticleClinical and vaccine immunology : CVI2012
Serological diagnosis of lung cystic hydatid disease using the synthetic p176 peptide.
Article in Clinical and vaccine immunology : CVI, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts?Parasitology research · 2023Article
- Cystic Echinococcosis in Hospitalized Adult Patients from Western Romania: 2007-2022.Microorganisms · 2023Article
- Primary isolated extraluminal hydatid cyst of left pulmonary artery.International journal of surgery case reports · 2023Article
- Hydatid Disease: A Radiological Pictorial Review of a Great Neoplasms Mimicker.Diagnostics (Basel, Switzerland) · 2023Review
- Proteomics investigation of human sera for determination of postoperative indicators of pulmonary cystic echinococcosis.Journal of cardiothoracic surgery · 2023Article
- Medical treatment for an isolated renal multilocular hydatid cyst in an elderly: a case report.BMC nephrology · 2020Article
- Diagnostic urinary cfDNA detected in human cystic echinococcosis.Molecular and biochemical parasitology · 2020Article
- Surgery for parasitic lung infestations: roles in diagnosis and treatment.Journal of thoracic disease · 2018Review
- Diagnostic Accuracy of Antigen 5-Based ELISAs for Human Cystic Echinococcosis.PLoS neglected tropical diseases · 2016Article
- Primary Giant Splenic Echinococcal Cyst Treated by Laparoscopy.The American journal of tropical medicine and hygiene · 2016Review
- Factors Influencing the Serological Response in Hepatic Echinococcus granulosus Infection.The American journal of tropical medicine and hygiene · 2016Article
- Immunodiagnosis of human hydatid disease: Where do we stand?World journal of methodology · 2015Review
- Evaluation of a New Immunochromatographic Test Using Recombinant Antigen B8/1 for Diagnosis of Cystic Echinococcosis.Journal of clinical microbiology · 2015Article
- Parasitic pneumonia and lung involvement.BioMed research international · 2014Review
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Cystic hydatid disease (CHD) is a worldwide zoonosis caused by the larval stage of the dog tapeworm Echinococcus granulosus. Diagnosis is based on imagenological tools (abdominal ultrasound, chest X-rays, or computed tomography [CT] scan). Serological antibody-detecting assays, using diverse native antigens, have been used as a supportive diagnostic tool, but their sensitivities and specificities differ greatly. The use of synthetic peptides as antigens should provide more reliability and allow better assessment and comparison of test formats and case series. The synthetic peptide p176, corresponding to the N-terminal extreme of the subunit of antigen B (AgB8/1), has shown promising performances for diagnosis of CHD. We evaluated the performance of the synthetic peptide p176 for the diagnosis of pulmonary hydatid disease in an enzyme-linked immunosorbent assay (ELISA) format. Sixty-one serum samples from patients with a diagnosis of pulmonary hydatidosis confirmed by surgery and 128 from healthy volunteers were tested. The overall sensitivity and specificity of the p176 ELISA for lung CHD were 78.69% and 96.88%, respectively. On bivariate analysis, positive serum antibody reactions were associated with the presence of complications and with the number of cysts (single/multiple). Only the presence of persistent complications significantly associated with seropositivity on multivariate logistic regression analysis (odds ratio [OR], 9.58; 95% confidence interval [CI], 2.15 to 42.6; P = 0.003). The p176 ELISA performs well for the diagnosis of lung CHD and adds an easily reproducible diagnostic assay to the existing diagnostic tools.
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