ArticleClinical and vaccine immunology : CVI2012
Serum IgG responses and seroconversion patterns to Cryptosporidium gp15 among children in a birth cohort in south India.
Article in Clinical and vaccine immunology : CVI, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Efficacy of medicinal plants in cryptosporidiosis treatment: a comprehensive review.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Review
- Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides FromFrontiers in cellular and infection microbiology · 2021Article
- Application of a salivary immunoassay in a prospective community study of waterborne infections.Water research · 2018Observational
- Asparagine-Linked Glycans ofMolecular & cellular proteomics : MCP · 2017Article
- Article
- Use of Pathogen-Specific Antibody Biomarkers to Estimate Waterborne Infections in Population-Based Settings.Current environmental health reports · 2016Review
- Serum Anti-Cryptosporidial gp15 Antibodies in Mothers and Children Less than 2 Years of Age in India.The American journal of tropical medicine and hygiene · 2015Article
- Rapid microfluidic immunoassay for surveillance and diagnosis of Cryptosporidium infection in human immunodeficiency virus-infected patients.Biomicrofluidics · 2015Article
- Cryptosporidiosis among children in an endemic semiurban community in southern India: does a protected drinking water source decrease infection?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Revisiting the global problem of cryptosporidiosis and recommendations.Tropical parasitologyArticle
- Cryptosporidiosis in children in the Indian subcontinent.Tropical parasitologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The correlates of protective immunity to cryptosporidiosis are not well understood. This study was conducted to assess the effect of maternal serum IgG against Cryptosporidium gp15 on responses to this antigen in children with (cases) and without (controls) PCR-confirmed cryptosporidial diarrhea. Maternal sera (n = 129) and sera from cases (n = 39) and controls (n = 90) collected at 3.5, 9, and 24 months of age were tested for serum IgG against Cryptosporidium gp15 by enzyme-linked immunosorbent assay (ELISA). Seroconversion patterns were evaluated by estimating probabilities of seroconversion along three time points based on the transition pathways by using a first-order Markov chain process and empirical Bayesian estimates. There was no difference in serum IgG levels or seropositivity rates to gp15 between cases and controls across all time points in children or in IgG levels to this antigen between mothers of cases and controls. The most common transition pathway can be described as a seronegative child at 3.5 months who seroconverts at 9 months and remains seropositive at 24 months. This pattern remained stable irrespective of the serological status of the mother or the case or control status of the child. Children were most likely to be exposed to Cryptosporidium for the first time between the ages of 3 and 9 months, and most of the children seroconverted by 24 months. The high degree of seroconversion among control children is suggestive of high rates of asymptomatic transmission in this region.
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