Evidence map›Paper›PMID 22517648›Full record

ArticleDiabetes2012

Paradigm shift or shifting paradigm for type 1 diabetes.

Maki Nakayama, George S Eisenbarth

Abstract readEditorialComment
In one paragraph

Article in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Maki Nakayama
George S Eisenbarth

Funding

Virginia Mason/UCHSC Autoimmune Prevention CenterU19AI050864 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HOLERS, VERNON MICHAEL · 2001 to 2011
$29.2M
UCHSC DIABETES ENDOCRINOLOGY RESEARCH CENTERP30DK057516 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HUTTON, JOHN C · 2000 to 2010
$14.0M
STRUCTURE PEPTIDE/CONSERVED T CELL RECEPTOR DETERMINING DIABETESR00DK080885 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI NAKAYAMA, MAKI · 2010 to 2012
$742k
NIAID NIH HHS U19 AI050864NIDDK NIH HHS P30 DK057516NIDDK NIH HHS R00 DK080885
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntibodies, MonoclonalDiabetes Mellitus, Type 1FemaleMaleReceptors, Antigen, T-Cell, alpha-betaAntibodies, MonoclonalReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID22517648
PMCPMC3331751

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.