ArticlePsychiatric genetics2012
Motor sequencing deficit as an endophenotype of speech sound disorder: a genome-wide linkage analysis in a multigenerational family.
Article in Psychiatric genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Three Unrelated Children With Childhood Apraxia of Speech: Exome Sequencing and Functional Gene Analysis Imply a Role of Laminin-511 in Early Neurodevelopment.Case reports in genetics · 2026Article
- Initial studies of the phenotype and persistence of speech motor delay (SMD).Clinical linguistics & phonetics · 2019Article
- Estimates of the prevalence of motor speech disorders in children with idiopathic speech delay.Clinical linguistics & phonetics · 2019Article
- A frequent acoustic sign of speech motor delay (SMD).Clinical linguistics & phonetics · 2019Article
- Sequential processing deficit as a shared persisting biomarker in dyslexia and childhood apraxia of speech.Clinical linguistics & phonetics · 2018Article
- A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: I. Development and Description of the Pause Marker.Journal of speech, language, and hearing research : JSLHR · 2017Review
- Language Impairment Resulting from a de novo Deletion of 7q32.1q33.Molecular syndromology · 2016Article
- Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech.PloS one · 2016Article
- Nonspeech Oral Movements and Oral Motor Disorders: A Narrative Review.American journal of speech-language pathology · 2015Review
- Linkage analysis in a Dutch population isolate shows no major gene for left-handedness or atypical language lateralization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains.Genes, brain, and behavior · 2015Article
- Insights into the genetic foundations of human communication.Neuropsychology review · 2015Review
- Direct and octave-shifted pitch matching during nonword imitations in men, women, and children.Journal of voice : official journal of the Voice Foundation · 2015Observational
- Genome-Wide Studies of Specific Language Impairment.Current behavioral neuroscience reports · 2014Review
- Genetic insights into the functional elements of language.Human genetics · 2013Review
- Deficits in sequential processing manifest in motor and linguistic tasks in a multigenerational family with childhood apraxia of speech.Clinical linguistics & phonetics · 2013Article
- Associations among measures of sequential processing in motor and linguistics tasks in adults with and without a family history of childhood apraxia of speech: a replication study.Clinical linguistics & phonetics · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThe aim of this pilot study was to investigate a measure of motor sequencing deficit as a potential endophenotype of speech sound disorder (SSD) in a multigenerational family with evidence of familial SSD.
methodsIn a multigenerational family with evidence of a familial motor-based SSD, affectation status and a measure of motor sequencing during oral motor testing were obtained. To further investigate the role of motor sequencing as an endophenotype for genetic studies, parametric and nonparametric linkage analyses were carried out using a genome-wide panel of 404 microsatellites.
resultsIn seven of the 10 family members with available data, SSD affectation status and motor sequencing status coincided. Linkage analysis revealed four regions of interest, 6p21, 7q32, 7q36, and 8q24, primarily identified with the measure of motor sequencing ability. The 6p21 region overlaps with a locus implicated in rapid alternating naming in a recent genome-wide dyslexia linkage study. The 7q32 locus contains a locus implicated in dyslexia. The 7q36 locus borders on a gene known to affect the component traits of language impairment.
conclusionThe results are consistent with a motor-based endophenotype of SSD that would be informative for genetic studies. The linkage results in this first genome-wide study in a multigenerational family with SSD warrant follow-up in additional families and with fine mapping or next-generation approaches to gene identification.
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