ArticlePlant signaling & behavior2012
Apoplastic exosome-like vesicles: a new way of protein secretion in plants?
Article in Plant signaling & behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 89 citations in OpenAlex.
- Engineered Plant-Derived Extracellular Vesicles: A Novel Strategy for Tumor-Targeted Therapy.Pharmaceutics · 2026Review
- Plant-derived exosome-like nanovesicles: dual-function platforms for anticancer therapy and drug delivery.Journal of translational medicine · 2026Review
- Plant-Derived Exosome-Like Nanoparticles: Mechanisms of Cross-Kingdom Regulation and Perspectives as Natural Drug Carriers for Disease Treatment.International journal of nanomedicine · 2026Review
- Green tea-derived exosome-like nanoparticles attenuate oxidative stress-induced skin senescence via modulation of p38 MAPK signaling.Frontiers in pharmacology · 2026Article
- Expression of endochitinase and exochitinase in lettuce chloroplasts increases plant biomass and kills fungal pathogen Candida albicans.Plant biotechnology journal · 2025Article
- Advancements and Challenges of Plant-derived Extracellular Vesicles in Anti-Cancer Strategies and Drug Delivery.Current drug delivery · 2025Review
- Frontiers of Plant-derived Exosomes from Research Methods to Pharmaceutical Applications in Plant-based Therapeutics.Current drug delivery · 2025Review
- Physical, biochemical, and biological characterization of olive-derived lipid nanovesicles for drug delivery applications.Journal of nanobiotechnology · 2024Article
- Extracellular vesicles of Norway spruce contain precursors and enzymes for lignin formation and salicylic acid.Plant physiology · 2024Article
- Isolation of Extracellular Vesicles from Agri-Food Wastes: A Novel Perspective in the Valorization of Agri-Food Wastes and By-Products.Foods (Basel, Switzerland) · 2024Review
- Plant-derived vesicle-like nanoparticles: A new tool for inflammatory bowel disease and colitis-associated cancer treatment.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Review
- Ginseng root-derived exosome-like nanoparticles protect skin from UV irradiation and oxidative stress by suppressing activator protein-1 signaling and limiting the generation of reactive oxygen species.Journal of ginseng research · 2024Article
- Isolation and Characterization of Extracellular Vesicles fromPlants (Basel, Switzerland) · 2023Article
- Development of Blueberry-Derived Extracellular Nanovesicles for Immunomodulatory Therapy.Pharmaceutics · 2023Article
- Plant-derived nanovesicles: Current understanding and applications for cancer therapy.Bioactive materials · 2023Article
- Plant-Derived Exosome-like Nanoparticles for Biomedical Applications and Regenerative Therapy.Biomedicines · 2023Review
- The Use of Medicinal Plants in Blood Vessel Diseases: The Influence of Gender.Life (Basel, Switzerland) · 2023Review
- Therapeutic potential and pharmacological significance of extracellular vesicles derived from traditional medicinal plants.Frontiers in pharmacology · 2023Review
- Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges.Cell communication and signaling : CCS · 2022Review
- Plant-Derived Exosomes as a Drug-Delivery Approach for the Treatment of Inflammatory Bowel Disease and Colitis-Associated Cancer.Pharmaceutics · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of apoplastic proteins without predicted signal peptide in the gene sequence suggests the existence of protein secretion independent of the ER/Golgi classical route. In animals, one of the pathways proposed for alternative protein secretion involves the release of exosomes to the extracellular space. Although this pathway has not been dissected in plants some indirect evidence is emerging. We have reported that apoplastic fractions of sunflower seeds contain exosome-like vesicles. Besides, these vesicles are enriched in the lectin Helja, which is immunolocalized in the extracellular space even if it the protein has no predicted signal peptide. Here we show that Helja is not glycosylated and its secretion is insensitive to brefeldin A, two of the major characteristics to discard ER/Golgi-mediated protein transport. Moreover, the levels of Helja in sunflower extracellular vesicles are not affected by brefeldin A treatment. Our results suggest that Helja could be exported through an exosome-mediated pathway and point out that this mechanism may be responsible for the secretion of at least part of the leaderless proteins detected in the extracellular compartment of plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.