ArticleBiomaterials2012
Nanotopography as modulator of human mesenchymal stem cell function.
Article in Biomaterials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 140 citations in OpenAlex.
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- Nanofibers in Glioma Therapy: Advances, Applications, and Overcoming Challenges.International journal of nanomedicine · 2025Review
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- Non-viral gene delivery to human mesenchymal stem cells: a practical guide towards cell engineering.Journal of biological engineering · 2023Review
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- Biomaterials with structural hierarchy and controlled 3D nanotopography guide endogenous bone regeneration.Science advances · 2021Article
- ECM-Mimetic Nylon Nanofiber Scaffolds for Neurite Growth Guidance.Nanomaterials (Basel, Switzerland) · 2021Article
- The effect of carbon nanotubes on osteogenic functions of adipose-derived mesenchymal stem cellsBioactive materials · 2021Article
- Article
- Predicting gene expression using morphological cell responses to nanotopography.Nature communications · 2020Article
- The Implication of Spatial Statistics in Human Mesenchymal Stem Cell Response to Nanotubular Architectures.International journal of nanomedicine · 2020Article
- Surface bioactivation of PEEK by neutral atom beam technology.Bioactive materials · 2019Article
- Directional Topography Influences Adipose Mesenchymal Stromal Cell Plasticity: Prospects for Tissue Engineering and Fibrosis.Stem cells international · 2019Article
- Control of cell behaviour through nanovibrational stimulation: nanokicking.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2018Review
- Human mesenchymal stem cell basal membrane bending on gratings is dependent on both grating width and curvature.Scientific reports · 2018Article
- Nanoengineered, cell-derived extracellular matrix influences ECM-related gene expression of mesenchymal stem cells.Biomaterials research · 2018Article
- Article
- The Functional Response of Mesenchymal Stem Cells to Electron-Beam Patterned Elastomeric Surfaces Presenting Micrometer to Nanoscale Heterogeneous Rigidity.Advanced materials (Deerfield Beach, Fla.) · 2017Article
- Control of Cell Alignment and Morphology by Redesigning ECM-Mimetic Nanotopography on Multilayer Membranes.Advanced healthcare materials · 2017Article
- Correlation of focal adhesion assembly and disassembly with cell migration on nanotopography.Integrative biology : quantitative biosciences from nano to macro · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Nanotopography changes human mesenchymal stem cells (hMSC) from their shape to their differentiation potential; however little is known about the underlying molecular mechanisms. Here we study the culture of hMSC on polydimethylsiloxane substrates with 350 nm grating topography and investigate the focal adhesion composition and dynamics using biochemical and imaging techniques. Our results show that zyxin protein plays a key role in the hMSC response to nanotopography. Zyxin expression is downregulated on 350 nm gratings, leading to smaller and more dynamic focal adhesion. Since the association of zyxin with focal adhesions is force-dependent, smaller zyxin-positive adhesion as well as its higher turnover rate suggests that the traction force in focal adhesion on 350 nm topography is decreased. These changes lead to faster and more directional migration on 350 nm gratings. These findings demonstrate that nanotopography decreases the mechanical forces acting on focal adhesions in hMSC and suggest that force-dependent changes in zyxin protein expression and kinetics underlie the focal adhesion remodeling in response to 350 nm grating topography, resulting in modulation of hMSC function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.