Trial reportJournal of the American College of Cardiology2012
Coronary arterial 18F-sodium fluoride uptake: a novel marker of plaque biology.
Trial report in Journal of the American College of Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 241 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Rosuvastatin Effect on Atherosclerotic Plaque Metabolism - a Subclinical Atherosclerosis Imaging Study With 18F-NaF PET-CT
Open the trial in the graphAn Observational PET/CT Study Examining the Role of Active Valvular Calcification and Inflammation in Patients With Aortic Stenosis
Dual Antiplatelet Therapy to Inhibit Coronary Atherosclerosis and Myocardial Injury in Patients With Necrotic High-Risk Coronary Plaque Disease
Prediction of Recurrent Events With 18F-Fluoride to Identify Ruptured and High-risk Coronary Artery Plaques in Patients With Myocardial Infarction
Characterizing Vulnerable Plaques in Non-ST-Elevation Myocardial Infarction Using 18F-NaF Positron Emission Tomography - Cardiac Magnetic Resonance Imaging: A Feasibility Study
Validation of PET-MRI for Cardiovascular Disease
In-vivo Thrombus Imaging With 18F-GP1, a Novel Platelet PET Radiotracer
Who cites it
241 citing papers in PubMed, 1 synthesis or guideline pooled it, 484 citations in OpenAlex.
- Sodium fluoride in cardiovascular disorders: A systematic review.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Pooled it
- Head-to-head comparison ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024Trial
- Effect of Denosumab or Alendronate on Vascular Calcification: Secondary Analysis of SALTIRE2 Randomized Controlled Trial.Journal of the American Heart Association · 2024Trial
- The effect of Vitamin-KJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Trial
- Vascular uptake onJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Trial
- CoronaryCirculation. Cardiovascular imaging · 2020Trial
- Ticagrelor to Reduce Myocardial Injury in Patients With High-Risk Coronary Artery Plaque.JACC. Cardiovascular imaging · 2020Trial
- Trial
- Thoracic aorta calcification but not inflammation is associated with increased cardiovascular disease risk: results of the CAMONA study.European journal of nuclear medicine and molecular imaging · 2017Trial
- CD80 as an Important Immune Mediator and Therapeutic Target in Atherosclerosis.International journal of molecular sciences · 2026Review
- Coronary artery disease imaging with total-body PET.The British journal of radiology · 2026Review
- Next-Generation Cardiovascular Imaging in Precision Medicine: Integrating Functional Imaging, Artificial Intelligence, Biomarkers, and Personalized Risk Stratification.Diagnostics (Basel, Switzerland) · 2026Review
- Association of Relative Pericoronary Adipose Tissue Attenuation with Coronary Artery Calcification Severity.Medicina (Kaunas, Lithuania) · 2026Article
- Review
- From incidental positron emission uptake toFrontiers in cardiovascular medicine · 2026Review
- PET Imaging of Carotid Atherosclerosis: Methodology, Implications, and Applications in Neurovascular Disease.Stroke · 2026Review
- Article
- Long Axial Field of View PET: A New Era of Quantitative PET Imaging for Prospective Applications Beyond Classical Theranostics.PET clinics · 2025Review
- Auto-segmentation, radiomic reproducibility, and comparison of radiomics between manual and AI-derived segmentations for coronary arteries in cardiac [EJNMMI physics · 2025Article
- Estimating inflammatory risk in atherosclerotic cardiovascular disease: plaque over plasma?European heart journal. Cardiovascular Imaging · 2025Review
181 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesWith combined positron emission tomography and computed tomography (CT), we investigated coronary arterial uptake of 18F-sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) as markers of active plaque calcification and inflammation, respectively.
backgroundThe noninvasive assessment of coronary artery plaque biology would be a major advance particularly in the identification of vulnerable plaques, which are associated with specific pathological characteristics, including micro-calcification and inflammation.
methodsWe prospectively recruited 119 volunteers (72 ± 8 years of age, 68% men) with and without aortic valve disease and measured their coronary calcium score and 18F-NaF and 18F-FDG uptake. Patients with a calcium score of 0 were used as control subjects and compared with those with calcific atherosclerosis (calcium score >0).
resultsInter-observer repeatability of coronary 18F-NaF uptake measurements (maximum tissue/background ratio) was excellent (intra-class coefficient 0.99). Activity was higher in patients with coronary atherosclerosis (n = 106) versus control subjects (1.64 ± 0.49 vs. 1.23 ± 0.24; p = 0.003) and correlated with the calcium score (r = 0.652, p < 0.001), although 40% of those with scores >1,000 displayed normal uptake. Patients with increased coronary 18F-NaF activity (n = 40) had higher rates of prior cardiovascular events (p = 0.016) and angina (p = 0.023) and higher Framingham risk scores (p = 0.011). Quantification of coronary 18F-FDG uptake was hampered by myocardial activity and was not increased in patients with atherosclerosis versus control subjects (p = 0.498).
conclusions18F-NaF is a promising new approach for the assessment of coronary artery plaque biology. Prospective studies with clinical outcomes are now needed to assess whether coronary 18F-NaF uptake represents a novel marker of plaque vulnerability, recent plaque rupture, and future cardiovascular risk. (An Observational PET/CT Study Examining the Role of Active Valvular Calcification and Inflammation in Patients With Aortic Stenosis; NCT01358513).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.