Evidence map›Paper›PMID 22516147›Full record

ArticleSchizophrenia bulletin2012

The validity of the 16-item version of the Prodromal Questionnaire (PQ-16) to screen for ultra high risk of developing psychosis in the general help-seeking population.

Helga K Ising, Wim Veling, Rachel L Loewy, Marleen W Rietveld, Judith Rietdijk, Sara Dragt, Rianne M C Klaassen, Dorien H Nieman, Lex Wunderink, Don H Linszen and 1 more

Open access · bronzeAbstract readValidation Study
In one paragraph

Article in Schizophrenia bulletin, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 249 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 5 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

249 citing papers in PubMed, 5 syntheses or guidelines pooled it, 447 citations in OpenAlex.

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  6. Dyadic patterns of abstinence from smoking in dual-smoking couples enrolled in a pilot randomized clinical trial.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
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  7. Mechanisms of change in a randomized control pilot study of partner-involved financial incentive treatments for dual-smoking couples.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025
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  14. Early detection and intervention in at-risk mental states: rationale, structure, and clinical experience from a specialized outpatient service.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026
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189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Helga K IsingDepartment of Psychiatry, Parnassia Psychiatric Institute, Prinsegracht 63-65, 2512 EX, The Hague, The Netherlands. h.ising@parnassia.nl
Wim Veling
Rachel L Loewy
Marleen W Rietveld
Judith Rietdijk
Sara Dragt
Rianne M C Klaassen
Dorien H Nieman
Lex Wunderink
Don H Linszen
Mark van der Gaag
Parnassia Groep · NLAcademic Medical Center · NLEMGO Institute for Health and Care Research · NLGGZ Friesland · NLGGZ Rivierduinen · NLUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to bring about implementation of routine screening for psychosis risk, a brief version of the Prodromal Questionnaire (PQ; Loewy et al., 2005) was developed and tested in a general help-seeking population. We assessed a consecutive patient sample of 3533 young adults who were help-seeking for nonpsychotic disorders at the secondary mental health services in The Hague with the PQ. We performed logistic regression analyses and CHi-squared Automatic Interaction Detector decision tree analysis to shorten the original 92 items. Receiver operating characteristic curves were used to examine the psychometric properties of the PQ-16. In the general help-seeking population, a cutoff score of 6 or more positively answered items on the 16-item version of the PQ produced correct classification of Comprehensive Assessment of At-Risk Mental State (Yung et al., 2005) psychosis risk/clinical psychosis in 44% of the cases, distinguishing Comprehensive Assessment of At-Risk Mental States (CAARMS) diagnosis from no CAARMS diagnosis with high sensitivity (87%) and specificity (87%). These results were comparable to the PQ-92. The PQ-16 is a good self-report screen for use in secondary mental health care services to select subjects for interviewing for psychosis risk. The low number of items makes it quite appropriate for screening large help-seeking populations, thus enhancing the feasibility of detection and treatment of ultra high-risk patients in routine mental health services.

Indexed as

Prodromal SymptomsSurveys and QuestionnairesAdolescentAdultEarly DiagnosisFemaleHumansLogistic ModelsMalePsychometricsPsychotic DisordersReproducibility of ResultsRisk AssessmentROC CurveSchizophreniaSelf Report

Identifiers

PMID22516147
PMCPMC3713086
OpenAlexW2170372220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.