ArticleMolecular immunology2012
B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients.
Article in Molecular immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The adaptive immune receptors in a big data world.ImmunoHorizons · 2026Review
- Antigen nature and complexity influence human antibody light chain usage and specificity.Vaccine · 2016Article
- Receptor editing and genetic variability in human autoreactive B cells.The Journal of experimental medicine · 2016Article
- The analysis of clonal expansions in normal and autoimmune B cell repertoires.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Light chain editors of anti-DNA receptors in human B cells.The Journal of experimental medicine · 2014Article
- The promise and challenge of high-throughput sequencing of the antibody repertoire.Nature biotechnology · 2014Review
- Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Intrinsic bias and public rearrangements in the human immunoglobulin Vλ light chain repertoire.Genes and immunity · 2013Article
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3 authors.
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Abstract
We have developed a microarray to study the expression of L-chain V genes (V(L) genes) in healthy and SLE patient peripheral κ- and λ-sorted B cells. In all repertoires tested, one V(L) gene accounts for over 10% of all gene V(L) expression, consistent with positive selection acting on L-chains. While a few V(L) genes were highly expressed in all individuals, most V(L) genes were expressed at different levels. Some V(L) genes (5 out of a total of 78) were not detected. We attribute their absence from the repertoire to negative selection. Positive selection and negative selection were also found in SLE repertoires, but expression of V(L) genes was different; the differences point to less regulation of V(L) gene repertoires in SLE. Our data shows that V(L) gene expression is variable and supports a model where the L-chain repertoire is generated by both positive and negative selection on L-chains.
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