ArticleNeuroscience2012
Multisensory dysfunction accompanies crossmodal plasticity following adult hearing impairment.
Article in Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain Morphological Modifications in Congenital and Acquired Auditory Deprivation: A Systematic Review and Coordinate-Based Meta-Analysis.Frontiers in neuroscience · 2022Pooled it
- Visual cortical responses in age-related hearing loss show evidence for compensatory neuroplasticity.GeroScience · 2026Article
- Vibrotactile beat sensitivity in deaf individuals: behavioral and neural evidence.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Time course of visual plasticity following adult-onset deafness.Scientific reports · 2026Article
- The Neural Organization of Visual Information in the Auditory Cortex of the Congenitally Deaf.Human brain mapping · 2026Article
- Visual Reliance in Severe Hearing Loss: Visual Evoked Potentials (VEPs) Study.Audiology research · 2025Article
- Cortical evoked activity is modulated by the sleep state in a ferret model of tinnitus. A cross-case study.PloS one · 2024Article
- Brain spatial reconciliation through multisensory integration in the impact of pandemic fatigue on workplace.Frontiers in human neuroscience · 2024Article
- Audiovisual Integration for Saccade and Vergence Eye Movements Increases with Presbycusis and Loss of Selective Attention on the Stroop Test.Brain sciences · 2022Article
- Adult-Onset Hearing Impairment Induces Layer-Specific Cortical Reorganization: Evidence of Crossmodal Plasticity and Central Gain Enhancement.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life.Therapeutic advances in chronic disease · 2019Review
- Compensatory Plasticity in the Lateral Extrastriate Visual Cortex Preserves Audiovisual Temporal Processing following Adult-Onset Hearing Loss.Neural plasticity · 2019Article
- Transient and localized optogenetic activation of somatostatin-interneurons in mouse visual cortex abolishes long-term cortical plasticity due to vision loss.Brain structure & function · 2018Article
- Somatosensory Cross-Modal Reorganization in Adults With Age-Related, Early-Stage Hearing Loss.Frontiers in human neuroscience · 2018Article
- Is territorial expansion a mechanism for crossmodal plasticity?The European journal of neuroscience · 2017Article
- Article
- Synaptic Basis for Cross-modal Plasticity: Enhanced Supragranular Dendritic Spine Density in Anterior Ectosylvian Auditory Cortex of the Early Deaf Cat.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Cross-Modal Re-Organization in Clinical Populations with Hearing Loss.Brain sciences · 2016Review
- The Current Status of Somatostatin-Interneurons in Inhibitory Control of Brain Function and Plasticity.Neural plasticity · 2016Review
- Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage.Neural plasticity · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Until now, cortical crossmodal plasticity has largely been regarded as the effect of early and complete sensory loss. Recently, massive crossmodal cortical reorganization was demonstrated to result from profound hearing loss in adult ferrets (Allman et al., 2009a). Moderate adult hearing loss, on the other hand, induced not just crossmodal reorganization, but also merged new crossmodal inputs with residual auditory function to generate multisensory neurons. Because multisensory convergence can lead to dramatic levels of response integration when stimuli from more than one modality are present (and thereby potentially interfere with residual auditory processing), the present investigation sought to evaluate the multisensory properties of auditory cortical neurons in partially deafened adult ferrets. When compared with hearing controls, partially-deaf animals revealed elevated spontaneous levels and a dramatic increase (∼2 times) in the proportion of multisensory cortical neurons, but few of which showed multisensory integration. Moreover, a large proportion (68%) of neurons with somatosensory and/or visual inputs was vigorously active in core auditory cortex in the absence of auditory stimulation. Collectively, these results not only demonstrate multisensory dysfunction in core auditory cortical neurons from hearing impaired adults but also reveal a potential cortical substrate for maladaptive perceptual effects such as tinnitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.